ARA 290 peptide is designed to eliminate chronic pain and inflammation.
Peptides are naturally occurring compounds that are present in every living cell.
These short chains of amino acids serve many different biological purposes and functions.
As a result, peptides like ARA 290 offer means to safe, affordable pain management.
Learn more about ARA 290 peptide and its top 5 benefits, below:
What is ARA 290 Peptide?
Are you sick and tired of being in pain?
Unfortunately, pain and discomfort are a normal part of the human existence.
When men age they experience more body aches, tenderness, and inflammation.
And, while pain is a normal part of life, it can begin to interfere with your life once levels become too intolerable.
Consequently, chronic pain and inflammation are serious issues that greatly influence well-being and quality of life.1
As a result, you shouldn’t settle for the status quo.
There are other options than prescription medications for pain management.
In general, these substances (i.e. opioids) produce more nasty side effects than the issue it intends to resolve.
Accordingly, it leaves many men searching for alternative remedies to chronic pain and inflammation.
ARA 290 peptide is one of those alternatives.
The peptide is specifically designed to manage pain and promote healing.
For this reason, ARA 290 offers safe and affordable means to pain management.
ARA 290 peptide is derived from Erythropoietin (EPO).2
Erythropoietin has been useful for decades thanks to its ability to stimulate red blood cell production within bone marrow.
Therefore, EPO can influence blood pressure and promote cellular health, along with protecting neurotransmitters.
ARA 290 consists of 11 amino acids that are entirely derived from the helix beta domain of Erythropoietin (EPO).
Benefits of ARA 290 Peptide
It’s estimated that nearly 1 in 4 Americans suffer from frequent chronic pain.
Chronic pain has been linked to several physical and mental conditions, as well as contributes to high health care costs.
Even worse, it’s difficult to accurately predict the number of adults suffering from severe pain and inflammation.
In fact, some estimates predict that nearly half of American adults manage some type of pain or discomfort.
Unfortunately, in the past, paint treatment options have been severely handicapped.
Previously, patients were largely restricted to prescription pain meds and other substances that have proven harmful.
Consequently, ARA 290 peptide promises to offer something different.
The reported benefits of the peptide range from accelerated healing and pain management to restoring nerve damage and reducing inflammation.
Here’s a look at the top benefits of ARA 290 peptide:
- Pain Management
- Reduces Inflammation
- Promotes Healing & Wound Repair
- Restores Nerve Damage
- Reduces Symptoms of Diabetes
Moreover, ARA 290 peptide has demonstrated the ability to reduce HbA1c and improve cholesterol.
Despite it all, ARA 290 has yet to receive FDA approval since results remain in the trial stages.
Nevertheless, the clinical research is very promising and offers hope for a natural alternative for pain management.
Now, let’s examine the benefits of ARA 290 peptide in more detail:
#1. Pain Management
There are more than 25 million adults that have pain every day, for 3 months or more, according to the National Institutes of Health (NIH).3
Even worse, nearly 40 million Americans (17% of U.S. adults) experience severe levels of pain.
ARA 290 peptide is engineered to combat all types of pain.
For this reason, ARA 290 is capable of treating both short-term, intense episodes of pain along with long-term, chronic pain.
The first major breakthrough occurred in 2016 when a study discovered a new mechanism for treating pain.4
It was a noteworthy discovery that confirmed what previous, smaller clinical studies had concluded about ARA 290 peptide.5
Researchers believe the peptide features the ability to block receptors that contribute to the sensation of pain.
As a result, ARA 290 demonstrates a strong ability to reduce pain by 30 days with continual use.
More importantly, pain may become non-existent within 6 months with the proper supplementation.
The peptide eliminates pain by decreasing reactivity in nerve cells, thus making the body less responsive to those negative sensations.
#2. Reduces Inflammation
ARA 290 peptide also features the capability to reduce inflammation.6
In general, swelling and other signs of inflammation are common with chronic pain.
Often, the body is not healing properly and becomes restricted.
Furthermore, when a part of the body gets injured the first response is for it to swell before pain and discomfort becomes apparent.
In the past, the common solution was to prescribe pain medication which generally features a long list of side effects.
What’s more, pain medication is notoriously addictive and easy to abuse.
ARA 290 peptide, on the other hand, does not demonstrate the same qualities for treating pain and inflammation.
The peptide features the ability to down-regulate inflammation which usually contributes to less discomfort.
In general, severe pain follows intense swelling which is why managing both is crucial.
Thankfully, ARA 290 peptide demonstrates the ability to treat both sources.
First, ARA 290 utilizes a process known as paracrine signaling.7
Paracrine signaling decreases pathways that contribute to inflammation.
It’s a crucial step toward preserving your health considering chronic inflammation is the root cause of many diseases.
#3. Promotes Healing & Recovery
Sadly, inflammation and pain is often caused by a serious injury.
Whenever this occurs the quality of life can be completely reversed.
Chronic pain and inflammation not only produce discomfort, but also can lead to long-term health problems.
As a result, it’s essential to rely on supplements that promote healing and recovery.
Peptides feature several qualities including the ability to accelerate healing.
These compounds stimulate natural processes in the body that improve recovery time for major injuries and wounds.
In fact, many peptides are renowned for their ability to treat a variety of skin conditions, including healing burn wounds.
ARA 290 peptide is noteworthy for promoting healing and recovery, especially since it regulates inflammation and pain levels.
#4. Nerve Repair & Regeneration
ARA 290 peptide not only prevents pain but also restores nerves in the process.
While research remains limited, the initial clinical studies regarding the peptide are extremely promising.
The initial research has demonstrated that ARA 290 restores the number of nerves, along with the connective strength between each nerve.8
The Phase 2b trial featured 64 patients with painful neuropathy.
And, after nearly a month studying, concluded that ARA 290 “provided a significant increase (23 percent) in the corneal nerve fiber abundance”.
Even better, as patients noticed the nerve repair they also experienced improved functional activity.
Lastly, the study (like other clinical research dedicated to ARA 290) did not find anything harmful about taking ARA 290.
#5. Diabetes Treatment
ARA 290 peptide also features the ability to reduce symptoms associated with diabetes.
The 2014 study determined that ARA 290 lowers the symptoms of neuropathic pain.
Moreover, ARA 290 peptide demonstrated several critical biomarkers that are indicators of good health.
The study was conducted on patients suffering from type 2 diabetes.
Accordingly, the Phase 2 study concluded that subjects enjoyed remarkable improvements in several areas of health.
In fact, among the most noteworthy, was that ARA 290 accelerates the rate of healing.
The discovery is groundbreaking since one of the notorious symptoms of diabetes is the inability to recover quickly from injuries, including wounds.
Thus, while ARA 290 will not cure diabetes, it can at least provide relief from some of its worse side effects.
Frequently Asked Questions (FAQs)
Do you have questions or concerns?
Here are some frequently asked questions about ARA 290 peptide:
How does it work?
ARA 290 peptide was developed by Ariam Pharmaceuticals.
The purpose of the peptide is to offer an alternative to conventional forms of pain management.
Consequently, ARA 290 reduces inflammation and chronic pain, along with several other benefits.
ARA 290 stimulates red blood cell production as well as regulates Erythropoietin (EPO).
EPO binds to the Innate Repair Receptor (IRR) – a prime target for chronic inflammation and pain.
Is ARA 290 peptide safe?
Yes, ARA 290 is completely safe.
There is no evidence that the peptide produces any unwanted side effects.
Several clinical studies have not discovered any warning signs or serious issues.
In fact, most experts consider peptides like ARA 290 far safer than prescription medication designed for treating pain.
Regardless, ARA 290 is still being researched and is not approved by the FDA.
Nonetheless, the peptide has reached Phase II clinical trials for several neuropathic conditions, including pain management.
Still, we suggest speaking with a physician before starting any new supplement.
It’s impossible to predict how a substance will interact with other prescription medication or preexisting conditions.
Therefore, speak to a doctor before considering ARA 290 peptide.
What is the best dosage for ARA 290 peptide?
There are no “official” guidelines for correct dosage of ARA 290 peptide.
The substance is not regulated by the FDA which restricts universal directions on proper use.
Be that as it may, there are many that have experimented with ARA 290 and offer helpful advice.
In general, it’s best to start with a low dose (i.e. 0.33 mL) for daily intake.
Usually, ARA 290 peptide is injected subcutaneously.
Moreover, some users consume as much as 4 mg/mL of the peptide each day.
Traditionally, people inject ARA 290 peptide until the pain goes away.
Therefore, those experiencing severe pain may require a higher dose for proper treatment.
Regardless, we wouldn’t exceed more than 30 days of initial treatment.
Most individuals report noticing differences in as little as 2-3 weeks.
Are there any other benefits to ARA 290 peptide?
Yes, there are many other benefits of ARA 290 worth exploring.
We already know that the peptide is effective at pain management and reducing inflammation.
However, more research is still necessary to confirm several of these other benefits are linked to the peptide:
- Treatment for Depression (Antidepressant)
- Increased Efficiency in Oxygen Utilization
- Prevents Development of Emphysema
- Improves Kidney Function
- Treatment for Lupus Disease
- Increases Lifespan
Again, more research is necessary yet the initial findings of ARA 290 are encouraging.
Conclusion
ARA 290 is a game-changer like many other revolutionary peptides.
The peptide has the potential to replace conventional yet damaging remedies for pain, like prescription medication.
ARA 290 stimulates a natural production which inhibits pain nerves, and therefore restricts your sensation to it.
Furthermore, ARA 290 is known for reducing inflammation, promoting healing and recovery, as well as reducing the symptoms related to diabetes.
Meanwhile, there is an indication that ARA 290 will feature even more benefits in the near future.
Of course, more research is still necessary yet the benefits of ARA 290 peptide are extremely promising.
ARA 290 is often paired with other peptides, like BPC-157, for additional health benefits.
References
- Dahlhamer J, Lucas J, Zelaya, C, et al. Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016. MMWR Morb Mortal Wkly Rep 2018;67:1001–1006. (source)
- Schoener B, Borger J. Erythropoietin Stimulating Agents. [Updated 2022 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. (source)
- Nahin RL. Estimates of pain prevalence and severity in adults: United States, 2012. J Pain. 2015 Aug;16(8):769-80. doi: 10.1016/j.jpain.2015.05.002. Epub 2015 May 29. PMID: 26028573; PMCID: PMC4562413. (source)
-
Zhang W, Yu G, Zhang M. ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception. Peptides. 2016;76:73-79. doi:10.1016/j.peptides.2016.01.003 (source)
-
Pulman KG, Smith M, Mengozzi M, Ghezzi P, Dilley A. The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model. Neuroscience. 2013;233:174-183. doi:10.1016/j.neuroscience.2012.12.022 (source)
-
Brines M, Dunne AN, van Velzen M, et al. ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes. Mol Med. 2015;20(1):658-666. Published 2015 Mar 13. doi:10.2119/molmed.2014.00215 (source)
-
Moreira LM, Takawale A, Hulsurkar M, et al. Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia. Nature. 2020;587(7834):460-465. doi:10.1038/s41586-020-2890-8 (source)
-
Dahan A, Dunne A, Swartjes M, et al. ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density [published correction appears in Mol Med. 2016 Oct 20;22:674]. Mol Med. 2013;19(1):334-345. Published 2013 Nov 8. doi:10.2119/molmed.2013.00122 (source)
See Also
LL-37 Peptide Review: Benefits, Side Effects, Dose, & More
Melanotan 2 Review: 7 Benefits Of This Tanning Peptide
Sermorelin And Ipamorelin Peptide Blend: 5 Amazing Benefits
Born and raised in Woodbridge, NJ, he graduated from the New Jersey Institute Of Technology with an MBA in eCommerce.His hobbies include beach volleyball, target shooting, and lifting.
Rob is also a Commercially rated pilot and Certified Flight Instructor (CFI), with over 1,500 hours of flight time.
- 12 USMC Ribbons Explained - March 15, 2023
- 9 Best Handguns for Seniors in 2023 - March 14, 2023
- 7 Best .380 Pistols For 2023 - March 7, 2023
