What are the best peptides for muscle growth?
It’s a question that bodybuilders and strength coaches receive often.
…And it’s one that experts would like to help resolve.
The issue of burning excess fat, building lean muscle, and adding strength/bulk has been a quest for men for ages.
Of course, there are various opinions on what is the best technique or manner for achieving the body composition you desire.
For some bodybuilders, the choice is to build a weight stack with muscle-enhancing compounds like peptides and SARMs.
There is emerging science and support for the use of peptides to improve muscle mass.
Learn more about the 8 Best Peptides for Muscle Growth in our complete breakdown.
IMPORTANT: The below peptides are NOT intended for those under the age of 18. If you are under the age of 18, do NOT consider taking them under any circumstances whatsoever.
One Other Thing: If peptides aren’t your thing, or you’re looking for an alternative way to boost testosterone without injections, consider checking out a supplement called Testosil.
It’s by far the best natural testosterone booster on the market.
Click Here to read our comprehensive Testosil review.
Table of Contents
#1. CJC-1295
Click Here to pick up CJC-1295 from our #1 rated source, Core Peptides.
Peptides are short strings of amino acids that provide building blocks for proteins.
Thus, they are essentially smaller versions of proteins and absorb into the body easier for that reason.
As a result, there is mounting evidence and support for the use of peptides like CJC-1295 to fuel muscle growth.
CJC-1295 DAC is a class of peptides that assist in stimulating the body’s natural production of growth hormones.1
However, unlike its near-cousin – CJC-1295 (GRF 1-29) features a far longer half-life.
In fact, CJC-1295 DAC can remain in the blood for as long as two weeks after dosage.
The reported benefits of supplementing CJC-1295 DAC in a weight stack include:
- Building Lean Muscle
- Losing Fat
- Improved Strength & Bone Structure
- Improved Stamina & Endurance
- Stronger Joints & Ligaments
- Improved Skin Complexion & Anti-Aging
Some users have also noted with the correct dosage improved sleep habits as well as mental well-being.
Notwithstanding, customers should consider speaking with a physician before starting any new supplement or cycle.
Unfortunately, quality clinical studies are still lacking on CJC-1295 DAC and other peptides.
Nonetheless, some clinical trials have demonstrated a considerable increase in growth hormone plasma levels.2
Learn more about CJC-1295 on the Core Peptides website here: www.CorePeptides.com
#2. TB-500
Click Here to pick up TB-500 from our #1 rated source, Core Peptides.
TB-500 is also considered one of the best peptides for muscle growth.
The synthetic equivalent of the amino acid Thymosin Beta-4, TB-500, functions by regulating polymerization.3
For this reason, it has the potential to heal acute injuries that generally have a slow rate of recuperating after symptoms appear.
Additionally, there is a word-of-mouth reputation that supports using TB 500 for stimulating muscle growth.
For starters, Thymosin does increase cellular respiration which is useful not only during physical activity but also during the recovery phase.
Secondly, the amino acid increases red blood cells and therefore improved oxygen intake as well as delivery to the muscles.
Thus, recovery times are improved between workouts while the protein also promotes new muscle growth.
The ability to shed unwanted weight and build lean muscle is made possible through the natural process of angiogenesis.
Fortunately, TB-500 is efficient at spurring angiogenesis thanks to how it promotes blood cell growth in existing vessels.4
Lastly, the peptide has demonstrated a desire to improve recovery time after injury since it repairs tissue and other mobility issues.
Since TB-500 is a synthetic alternative to Thymosin, you should focus on buying from a reliable manufacturer.
Core Peptides features the highest grade and purest TB-500 for sale at a competitive price in the United States.
You’ll receive free shipping on all U.S. orders that exceed $150.
Learn more about TB-500 on the Core Peptides website here: www.CorePeptides.com
#3. IGF-1 LR3
Click Here to pick up IGF-1 LR3 from our #1 rated source, Core Peptides.
LR3-IGF-I gets classified in what is known as a “Human Recombinant”.
In other words, a recombinant protein is one that is encoded with DNA that has been closed in an expression vector.
Consequently, recombinant proteins get manipulated from the native protein yet also assist in several crucial bodily functions.
These include stimulating natural processes like stimulating the production of proteins or modifying gene sequences.
In terms of a compound like IGF-I (Insulin-like Growth Factor), the peptide is purposely engineered to increase biological activity such as increasing muscle growth.5
Ironically, IGF-1 is at its highest levels during puberty, when it acts as one of the primary agents for building lean muscle.
The long[R3] form of IGF-1 is considered more potent and effective at developing lean muscle compared to its standard form.6
Some of the listed benefits of supplementing IGF-1 LR3 include:
- Improved Protein Synthesis
- Increased Cell Production & Health
- Improved Glucose Transport
- Increased RNA Synthesis
- Decreased Protein Degradation
There is still much to learn about IGF-1 LR3 and its chemically altered long-form version.
While more research is still necessary, one study from the NIH offered a positive perspective on IGF-1 LR37:
In addition to a direct anabolic effect on skeletal muscle — for example, the production of more protein — IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells.
Learn more about IGF-1 LR3 on the Core Peptides website here: www.CorePeptides.com
#4. Sermorelin
Click Here to pick up Sermorelin from our #1 rated source, Core Peptides.
Another one of the best peptides for muscle growth is Sermorelin.
Sermorelin acetate is a peptide analog of Growth Hormone-Releasing Hormone (GHRH).
As a result, the peptide is resourceful in diagnosing trouble spots in the body as well as providing anti-aging remedies.
Sermorelin functions by stimulating growth hormones and initial research is more promising compared to synthetic growth hormones (HGH).8
Consequently, it’s vital to note that Sermorelin is not a substitute for HGH or other performance-enhancing drugs.
Rather, the peptide serves as a promoter that helps generate the natural production of growth hormones.
Thus far, research has indicated that Sermorelin demonstrates anti-aging properties and could serve as an effective treatment for a variety of conditions.9
Interestingly enough, Sermorelin helps spur hormone production by engaging with the pituitary – an endocrine gland located at the base of the brain.10
In accordance, the peptide secretes hormones that control numerous bodily aspects, including:
- Muscle Growth
- Blood Pressure
- Libido
- Metabolism
- Pain Relief
Sermorelin supplementation avoids the same nasty side effects of synthetic HGH which include bone and tissue growth abnormalities, diabetes, and heart disease.
Additionally, the compound can influence a variety of composition issues ranging from muscle mass, bone density, strength, energy, and sexual function.
Finally, there is clinical support to also utilize Sermorelin as a stimulator for losing weight.11
You should avoid synthetic HGH and, rather, get many of the same stimulating effects from a peptide like Sermorelin.
Learn more about Sermorelin on the Core Peptides website here: www.CorePeptides.com
#5. BPC-157
Click Here to pick up BPC-157 from our #1 rated source, Core Peptides.
Body Protection Compound, or BPC-157, is another popular peptide to supplement in a weight stack.12
The primary characteristic of BPC-157 is the longer chain which consists of 15 amino acids.
The chain creates a partial sequence of the body protection compound (BPC) which is specifically developed to treat certain prevailing conditions.
For example, BPC-157 has been utilized in science to study how it alleviates stomach ulcers.13
Moreover, BPC-157 has promise in regards to treating skin, muscle, gastrointestinal, colon, and bone deficiencies.
Furthermore, the peptide is an absolute lifesaver in terms of acting as a repair agent.14
It’s welcoming news for athletes that need to speed up the recovery phase yet in a healthy and effective manner.
In general, ligaments and muscles are the two areas of the body that endure the most abuse in athletics as well as in life.
Therefore, having a peptide like BPC-157 that can fuel natural healing occurrences to get started faster is great news to your body!
Benefits of BPC-157
Here are just a few natural processes in the human body that BPC-157 is known to stimulate15:
- Angiogenesis: The process of forming new, healthy vessels and cells.
- Collagen Production: Fuels the process that creates a protein that provides structural support, elasticity, and strength to the body.
- Granulation Tissue: Tissue formed at the site of an injury and begins the healing process.
Athletes and bodybuilders are always craving a recovery aid like BPC-157 that is healthy and safe.
The problem is we still do not have a ton of clinical evidence to support peptides, even if the initial results are encouraging.
Nevertheless, you can shop for high-quality and pure peptides online that are completely safe and produced by U.S. suppliers like Core Peptides.
Despite resistance from Uncle Sam, some recent studies do support the use of peptides like BPC-157, including several from the NIH.16
More importantly, BPC-157 has yet to display any toxic effects in humans or other animals during clinical trials.
In spite of all the positive momentum, the peptide is not approved by the FDA and therefore only legally available for purchase with “research intentions”.
Learn more about BPC-157 on the Core Peptides website here: www.CorePeptides.com
#6. Tesamorelin
Click Here to pick up Tesamorelin from our #1 rated source, Core Peptides.
Tesamorelin is another amino acid chain that receives designation under the broad umbrella of “peptides”.
The compound is synthetically engineered as a peptide to mirror the sequence of that of a human growth hormone-releasing factor.
In other words, igniting the production of hormones in your body that lead to you burning fat as well as gaining lean muscle.
Thus, Tesamorelin has transformed into a popular peptide for muscle growth.
The compound is a type of Growth Hormone Releasing Hormone (GHRH).17
As a result, Tesamorelin stimulates the synthesis and release of endogenous growth hormones.
Like Sermorelin, it also targets the pituitary and can subsequently treat conditions related to the gland.
Additionally, there are other prevailing conditions that Sermorelin may be able to assist.
The most promising news results from a 2010 randomized placebo trial.18
The results concluded that Tesamorelin noticeably reduced visceral fat while also improving self-esteem.
Most importantly, the study did not witness any significant side effects from using Tesmaorelin.
Still, we always recommend speaking with a licensed physician before starting any new supplement.
Learn more about Tesamorelin on the Core Peptides website here: www.CorePeptides.com
#7. Ipamorelin
Click Here to pick up Ipamorelin from our #1 rated source, Core Peptides.
There are many in bodybuilding that consider Ipamorelin a hidden gem and easily one of the best peptides for muscle growth.
Why?
Ipamorelin significantly increases plasma growth hormone (GH) levels.
The scientific revelation has been confirmed in both animal and human studies, such as this promising one from the NIH.19
Ipamorelin is unique in that it also stimulates the production of IGF-1 – another popular peptide for gaining lean muscle and bulk (see above).
The scientific study concluded that Ipamorelin is potent and subsequently capable of stimulating systems that are related to growth and repair in the body.
Sadly, that study was completed in the late-1990s, and the federal government hasn’t given Ipamorelin the attention it deserves in research.
It’s very unfortunate considering the NIH study concluded with this statement:
The specificity of ipamorelin makes this compound a very interesting candidate for future clinical development.
The specific growth hormone (GH) releasing properties of Ipamorelin are noteworthy along with how safe and effective it appears.
For starters, Ipamorelin does not affect prolactin, which is vital to numerous bodily functions.
Secondly, the peptide does not appear to negatively influence the thyroid, cortisol, or stimulate the stress hormone ACTH.20
Third, Ipamorelin contributes to producing testosterone and sperm which may ultimately impact your libido.
Lastly, the peptide encourages weight loss by reducing hunger cravings while simultaneously developing lean muscle.
Nonetheless, more studies are necessary to reach a final conclusion on Ipamorelin even if the initial research is optimistic.
Ipamorelin is generally well-tolerated yet may produce undesirable effects.
It’s especially plausible if you already take prescription medication or mix with high levels of IGF-1.
Learn more about Ipamorelin on the Core Peptides website here: www.CorePeptides.com
#8. Hexarelin
Click Here to pick up Hexarelin from our #1 rated source, Core Peptides.
Hexarelin receives designation as a Growth Hormone Secretagogues (GHSs).21
Unless you work in the science community that name doesn’t matter so much as to the potential benefits of Hexarelin.
The compound increases plasma growth hormone (GH) levels comparable to other peptides like Ipamorelin.22
Moreover, the two peptides have shared the same fate from the NIH in which they both received positive feedback in the late 90’s yet have received very little attention since that point in time.
Nevertheless, the substance is currently undergoing phase II clinical trials as a potential treatment for growth hormone deficiency and congestive heart failure.
Core Peptides offers some of the highest grade and purity Hexarelin online.
Learn more about Hexarelin on the Core Peptides website here: www.CorePeptides.com
Best Peptide Stack For Muscle Growth
Click Here to pick up the TB -500 & BPC-157 blend from our #1 rated source, Core Peptides.
There is little doubt that the best peptide for muscle growth is a stack that combines BPC-157 with TB-500.
“Why these 2 peptides over all the other fantastic compounds we reviewed on this list?” – you may ask.
Simply because BPC-157 and TB-500 functional so well together.
The explosive combination provides maximum benefits to your body, especially in terms of tissue repair and injury protection.
These peptides produce the energy, focus, and endurance you need to hit the gym… and hard!
Furthermore, TB-500 and BPC-157 are outstanding as a team getting you back on the playing field sooner.
As a result, users notice an improved recovery time between workouts.
Moreover, TB-500 and BPC-157 have the advantage of producing improved flexibility and joint mobility.
You can stack with just about anyone but we suggest going with Core Peptides.
The U.S.-based company has been in operation since 2013 and doesn’t disappoint in terms of customer service.
They are also an industry leader in terms of research as their peptides must pass above 99% purity.
Core Peptides thoroughly tests its peptides using liquid chromatography-mass spectrometry (HPLC/MS) technology.
The high-performance testing ensures that the results are complete and accurate, ultimately providing customers with peace of mind.
Learn more about TB-500 and BPC-157 on the Core Peptides website here: www.CorePeptides.com
Conclusion
There is so much to get excited about in regards to peptides and their opportunity to revolutionize the fitness world.
For decades, athletes and bodybuilders have been desperately searching for a safe and healthy method for keeping their bodies at peak levels.
Unfortunately, the grind of the sport often leaves them sidelined with nagging, chronic injuries.
However, with peptides, an answer could exist that will enable athletes to heal and recover faster.
More importantly, the good news about peptides benefits ordinary, everyday people the most.
It’s an opportunity to build a weight stack that is healthy, potent, and actually gets you results!
Peptides have the potential to help individuals shed unwanted fat, build lean muscle, and recover faster.
References
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Alba M, Fintini D, Sagazio A, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. doi:10.1152/ajpendo.00201.2006 (source)
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Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. doi:10.1210/jc.2005-1536 (source)
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Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012;12(1):37-51. doi:10.1517/14712598.2012.634793 (source)
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Sosne G, Qiu P, Christopherson PL, Wheater MK. Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway. Exp Eye Res. 2007;84(4):663-669. doi:10.1016/j.exer.2006.12.004 (source)
- Puche, J.E., Castilla-Cortázar, I. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med 10, 224 (2012). https://doi.org/10.1186/1479-5876-10-224 (source)
- Assefa B, Mahmoud AM, Pfeiffer AFH, Birkenfeld AL, Spranger J, Arafat AM. Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes. Oxid Med Cell Longev. 2017;2017:3035184. doi:10.1155/2017/3035184 (source)
- Adams GR. Insulin-like growth factor in muscle growth and its potential abuse by athletes. West J Med. 2001;175(1):7-9. (source)
- Saugy M, Robinson N, Saudan C, Baume N, Avois L, Mangin P. Human growth hormone doping in sport. Br J Sports Med. 2006;40 Suppl 1(Suppl 1):i35-i39. doi:10.1136/bjsm.2006.027573 (source)
- Izdebski J, Pinski J, Horvath JE, Halmos G, Groot K, Schally AV. Synthesis and biological evaluation of superactive agonists of growth hormone-releasing hormone. Proc Natl Acad Sci U S A. 1995;92(11):4872-4876. doi:10.1073/pnas.92.11.4872 (source)
- El Sayed SA, Fahmy MW, Schwartz J. Physiology, Pituitary Gland. [Updated 2022 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. (source)
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Lance VA, Murphy WA, Sueiras-Diaz J, Coy DH. Super-active analogs of growth hormone-releasing factor (1-29)-amide. Biochem Biophys Res Commun. 1984;119(1):265-272. doi:10.1016/0006-291x(84)91647-4 (source)
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Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780. doi:10.1152/japplphysiol.00945.2010 (source)
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Luetic K, Sucic M, Vlainic J, et al. Cyclophosphamide induced stomach and duodenal lesions as a NO-system disturbance in rats: L-NAME, L-arginine, stable gastric pentadecapeptide BPC 157. Inflammopharmacology. 2017;25(2):255-264. doi:10.1007/s10787-017-0330-7 (source)
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Sikiric P. The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology. 1999;7(1):1-14. doi:10.1007/s10787-999-0022-z (source)
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Tkalcević VI, Cuzić S, Brajsa K, et al. Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. Eur J Pharmacol. 2007;570(1-3):212-221. doi:10.1016/j.ejphar.2007.05.072 (source)
- Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066-19077. Published 2014 Nov 19. doi:10.3390/molecules191119066 (source)
- Olarescu NC, Gunawardane K, Hansen TK, et al. Normal Physiology of Growth Hormone in Adults. [Updated 2019 Oct 16]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. (source)
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Falutz J, Potvin D, Mamputu JC, et al. Effects of tesamorelin, a growth hormone-releasing factor, in HIV-infected patients with abdominal fat accumulation: a randomized placebo-controlled trial with a safety extension. J Acquir Immune Defic Syndr. 2010;53(3):311-322. doi:10.1097/QAI.0b013e3181cbdaff (source)
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Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561. doi:10.1530/eje.0.1390552 (source)
- Allen MJ, Sharma S. Physiology, Adrenocorticotropic Hormone (ACTH) [Updated 2021 Aug 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. (source)
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Bellone J, Bartolotta E, Sgattoni C, et al. Hexarelin, a synthetic GH-releasing peptide, is a powerful stimulus of GH secretion in pubertal children and in adults but not in prepubertal children and in elderly subjects. J Endocrinol Invest. 1998;21(8):494-500. doi:10.1007/BF03347334 (source)
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Guerlavais V, Boeglin D, Mousseaux D, et al. New active series of growth hormone secretagogues. J Med Chem. 2003;46(7):1191-1203. doi:10.1021/jm020985q (source)
See Also
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Born and raised in Woodbridge, NJ, he graduated from the New Jersey Institute Of Technology with an MBA in eCommerce.His hobbies include beach volleyball, target shooting, and lifting.
Rob is also a Commercially rated pilot and Certified Flight Instructor (CFI), with over 1,500 hours of flight time.
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