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Delta Sleep Inducing Peptide (DSIP) Review: 6 Big Benefits

DSIP peptide seeks to provide you with a good night’s rest.

The peptide offers much promise in terms of providing better sleep and treating drug withdrawals, among other benefits.

These benefits include opportunities to restore hormone imbalances and other damaging effects related to aging.

Learn more about the top 6 benefits of DSIP peptide. 

DSIP Peptide: 6 Big Benefits

dsip delta sleep inducing peptide benefits

Note: This is simply a review. Click Here to visit the official Core Peptides website.

There are many studies that indicate that 6-8 hours of quality, uninterrupted sleep are critical to good health.

For starters, a good night’s sleep is indicative of good signs of physical health, including optimal testosterone levels.

Moreover, getting the body enough rest also does wonders for the mind and soul.

For this reason, previous reports have found that quality sleep is also linked to good mental health.

Unfortunately, that is not often the case for many people that struggle to get enough sleep.

Thankfully, DSIP peptide offers a top remedy for those that suffer from insomnia or, even, a depletion of quality sleep at night.

Those that do not get enough rest can attest to the many complications that arise from it.

Fortunately, DSIP peptide features a solution, including the following benefits:

  1. Promotes Better Sleep Habits
  2. Substance Abuse & Opioid Withdrawals
  3. Anxiety & Depression (Improved Mood)
  4. Pain Management (Acute & Chronic Pain)
  5. Hormone Optimization (Anti-Aging)
  6. Improved Testosterone Production

The benefits of DSIP are possible through the healing and restorative powers of peptides.

Peptides are short chains of amino acids that serve as building blocks for proteins.

As such, peptides have several important health qualities, including assisting with a good night’s rest.

Here is a complete breakdown of each benefit associated with DSIP peptide:

#1. Better Quality Sleep

dsip can help improve sleep quality

There is nothing that beats a good night’s rest.

Sadly, too many people can relate to what it feels like not to get enough rest or wake up still feeling tired.

Often, people blame themselves, assuming that something is out of the ordinary and there are few things they can do.

Today, there are many sleep remedies that are promoted yet very few are safe or effective.

The good news is that people that are sleep-deprived do not have to lose hope.

Studies indicate that DSIP peptide have an important influence over the quality of sleep humans receive.1

In the past, patients with insomnia have experimented with DSIP peptide, among other sleep disorders (more details, below).2

Even better, recent research suggests that DSIP peptide can help out many others that wake up feeling tired and exhausted.3

The peptide has been shown to increase LH which may activate hypothalamic neural circuitry that occurs during sleep.

In other words, research has shown that DSIP peptide can do the following:

  • Regulate sleep including better habits.
  • Improve the quality of sleep (REM sleep).
  • Suppress paradoxical sleep (insomnia) and narcolepsy.
  • Improve nighttime rest while reducing daytime sedation.

Therefore, while the mechanism of action for DSIP (and the gene that encodes it remains unknown), the peptide has been found in both free / bound forms in the hypothalamus, limbic system, and pituitary.4 5 6

The latter is especially noteworthy considering that the pituitary gland affects the brain.

For this reason, DSIP (and several other peptides) have been linked to cognitive and mental health.

Thus, it’s not surprising that DSIP peptide features many benefits associated with improved brain function and reduced stress.

Treatment for Sleep Disorders

DSIP is unique in that, unlike other peptides, it has actually been heavily researched and studied.

DSIP peptide was discovered in the mid-1970s and, therefore, more research dedicated to it.

In fact, many studies have already found that DSIP improves the quality of sleep, among numerous other benefits.

Be that as it may, peptides are still relatively unknown to many that do not understand their health values.

Peptides such as DSIP are improving sleep habits safely and effectively.

Accordingly, DSIP peptide has been utilized in the past for those suffering from insomnia and narcolepsy.

The peptide treats sleep disorders differently than other remedies that attempt to influence how quickly you fall asleep.

Instead, DSIP peptide is renowned for improving the quality of sleep with a much more relaxing, enjoyable night’s rest.

#2. Substance Abuse (Alcohol & Opioid Withdrawal)

dsip can also help with substance abuse and alcohol withdrawal

The other really promising benefit of DSIP peptide is related to substance abuse treatment.

In the past, DSIP has offered promise as a remedy for opioid withdrawal.

Opioid withdrawal, and many other types of drug withdrawals, are infamously cruel and severe.

For this reason, patients that are admitted for drug withdrawals are often administered powerful medications to ease the side effects.

Studies reveal that DSIP influences opioid receptors which gives it the unique ability to treat severe withdrawals.7

Moreover, other research has shown that patients suffering from alcoholism and other types of substance abuse can find relief with DSIP.8

The clinical study revealed that 97% of patients had improved symptoms recovering from opioid abuse, compared to 87% of alcoholic patients.

Treatment for Addiction & Substance Abuse

The effects of addiction are devastating both to the patient and loved ones.

Unfortunately, many families are often left hopeless, finding no cure.

DSIP peptide may not solve substance abuse problems yet it can assist with recovery efforts.

The peptide has shown impressive signs of treating many forms of withdrawal, including alcohol and opioid abuse.

As such, DSIP peptide can assist during the early days of recovery when the patient is managing the worse symptoms of withdrawal.

Withdrawal is the necessary first step to get clean yet is painful to experience without the right treatment.

Consequently, make sure to speak with a licensed physician before detoxing from any substance and using counter-acting medications.

For many, it’s best to detox within a supervised setting where patients can receive immediate medical assistance.

#3. Treatment for Chronic Pain

dsip has been studied for its potential at alleviating chronic pain

The benefits of DSIP peptide are noteworthy considering the ability to impact physical and mental health.

There is no question that many people seek better sleep at night or reduced stress levels.

Moreover, the potential to influence emotions and mental disorders such as anxiety and depression.

While more research is necessary to observe how DSIP peptide may influence the brain, there is plenty of optimism.

DSIP peptide has been shown to reduce pain levels and assist with other symptoms related to chronic pain.

The study examined the pain levels in 7 patients suffering from neurotic disorders like migraines, chronic tinnitus, and panic attacks.9

And, concluded that DSIP significantly lowered the pain levels of 6 out of the 7 patients following a week of use.

Even better, a significant reduction in depressive states was also observed in the study, indicating that DSIP peptide could also treat depression.

DSIP peptide is unique in that it improves alertness and mood during the day without creating sedation effects when they are unwanted.

Still, the influence the peptide has on treating mental health remains questionable as more research is necessary.10

#4. Depression

delta sleep inducing peptides have also been studied for its effects on lowering depression

There is previous research that has hinted at the influence DSIP may play on the brain, especially in regard to mental health.

Unfortunately, not enough research has been dedicated to this subject yet what is known is that the peptide may treat depression and anxiety-related disorders.

The primary evidence exists from other research that has examined how DSIP peptide affects the body.

Accordingly, the stress-reducing properties of the peptide make it a prime candidate to treat depression.

Nonetheless, the potential for peptides to treat mental health disorders continues to have skeptics until more clinical studies are conducted.

Today, the use of DSIP peptide remains experimental until the alternative health remedy receives more mainstream attention.

Often, public support and pressure influence the types of substances the NIH and other health organizations decide to investigate.

#5. Hormone Optimization (Anti-Aging)

dsip for anti aging

Nobody wants to get old, especially when their physical and mental characteristics begin to erode.

Fortunately, aging is no longer viewed from the same perspective as it was years ago when people simply accepted it as fate.

Today, there are many anti-aging health remedies that offer reasonable means to affordable treatment.

Thus, seeking hormone optimization is one of the most critical aspects of fighting / reversing the signs of aging.

Previously, DSIP peptide has demonstrated the following benefits in regard to hormone optimization:

  • The ability of the peptide to modify thermogenesis.
  • A positive influence on heart rate and blood pressure.
  • Improved endorphin and cortisol levels.
  • Helped regulate diurnal and circadian rhythmicity.
  • Improved LH secretion contributes to better sleeping habits.
  • Improved pain threshold due to influence over opioid receptors.

What’s more, DSIP peptide is also connected to having antioxidant and detoxifying effects.11

For this reason, the anti-aging properties of DSIP are just beginning to get examined.

Nonetheless, at least one study has found that the peptide is linked to decreased cellular damage.12

#6. Improves Testosterone Production

delta sleep inducing peptides for increased testosterone

Testosterone has a powerful influence on your health.

In the early years, testosterone is abundant which is why most men are full of energy and vigor.

However, as the decades pass, testosterone production in the body generally declines.

As a result, peptides that improve testosterone levels are getting in higher demand.

Currently, not enough research has been evaluated to determine how DSIP peptide may influence testosterone.

Nevertheless, one study found that DSIP may indirectly increase levels due to its ability to improve luteinizing hormone (LH) secretion.13

Additionally, the peptide has been examined for its ability to inhibit the release of somatostatin.14

Somatostatin is a growth hormone-inhibiting hormone that works counterproductive to improving strength and overall health.

Finally, some research indicates that DSIP peptide may also have a positive influence on growth hormone (GH) production.

What is DSIP Peptide?

Delta-sleep-inducing peptide – otherwise known as DSIP – was first isolated from rabbits in 1964.

However, it wasn’t until the 1970s that the peptide began to receive more attention.

At first, the peptide was studied for its rare ability to influence sleep in rabbits, among other qualities.

DSIP peptide has also been linked to improving the central nervous system, including conditions like depression and insomnia.

Moreover, one of the early uses of DSIP has been for patients recovering from alcohol and opioid withdrawal.

Additionally, the peptide may offer long-term treatment for chronic pain.

Be that as it may, the peptide lacks clinical support in certain areas despite having multiple human and animal studies already conducted.

Despite being safe in low doses, the peptide also carries the risk of being misused in larger doses.

The mistreatment may result in unpleasant side effects such as dizziness, headaches, nausea, and fatigue.

As such, it never hurts to speak to a physician you trust before starting any new treatment.

Where To Buy Delta Sleep Inducing Peptides

While there are many vendors that sell DSIP, we highly recommend that you pick it up from a company called Core Peptides.

They are a market leader when it comes to peptides, and produce only the finest quality peptides money can buy.

They sell 5 mg bottles for $39 each, and provide discounts for larger orders.

Click Here to see their page on DSIP.


What happens when you do everything right and still cannot get enough sleep?

Sleep deprivation is a major issue and impacts just about every other area of health.

Nobody wants to wake up and walk around all day feeling like zombies.

Accordingly, consider the benefits of DSIP peptide which offers a solution to nighttime restlessness.

It can not only influence how much sleep you get but the quality of it.


  1. Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984;8(1):83-93. doi:10.1016/0149-7634(84)90022-8 (source)
  2. Monti JM, Debellis J, Alterwain P, Pellejero T, Monti D. Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs. Int J Clin Pharmacol Res. 1987;7(2):105-110. (source)
  3. Yehuda S, Carasso RL. DSIP–a tool for investigating the sleep onset mechanism: a review. Int J Neurosci. 1988;38(3-4):345-353. doi:10.3109/00207458808990695 (source)
  4. Barbier M, Risold PY. Understanding the Significance of the Hypothalamic Nature of the Subthalamic Nucleus. eNeuro. 2021;8(5):ENEURO.0116-21.2021. Published 2021 Oct 4. doi:10.1523/ENEURO.0116-21.2021 (source)
  5. Purves D, Augustine GJ, Fitzpatrick D, et al., editors. Neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates; 2001. (source)
  6. El Sayed SA, Fahmy MW, Schwartz J. Physiology, Pituitary Gland. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. (source)
  7. Dick P, Grandjean ME, Tissot R. Successful treatment of withdrawal symptoms with delta sleep-inducing peptide, a neuropeptide with potential agonistic activity on opiate receptors. Neuropsychobiology. 1983;10(4):205-208. doi:10.1159/000118012 (source)
  8. Dick P, Costa C, Fayolle K, Grandjean ME, Khoshbeen A, Tissot R. DSIP in the treatment of withdrawal syndromes from alcohol and opiates. Eur Neurol. 1984;23(5):364-371. doi:10.1159/000115715 (source)
  9. Larbig W, Gerber WD, Kluck M, Schoenenberger GA. Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study. Eur Neurol. 1984;23(5):372-385. doi:10.1159/000115716 (source)
  10. Chávez-Castillo M, Ortega Á, Cudris-Torres L, et al. Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?. Int J Mol Sci. 2021;22(19):10370. Published 2021 Sep 26. doi:10.3390/ijms221910370 (source)
  11. Mikhaleva II, Ivanov VT, Onoprienko LV, et al. Bioorg Khim. 2014;40(1):3-11. doi:10.1134/s1068162014010087 (source)
  12. Kutilin DS, Bondarenko TI, Kornienko IV, Mikhaleva II. Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging. Bull Exp Biol Med. 2014;157(5):616-619. doi:10.1007/s10517-014-2628-4 (source)
  13. Iyer KS, McCann SM. Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat. Brain Res Bull. 1987;19(5):535-538. doi:10.1016/0361-9230(87)90069-4 (source)
  14. Iyer KS, McCann SM. Delta sleep inducing peptide inhibits somatostatin release via a dopaminergic mechanism. Neuroendocrinology. 1987;46(1):93-95. doi:10.1159/000124802 (source)

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What are the benefits of DSIP? Learn more about this powerful peptide and its rare ability to improve mood, sleep, and chronic pain.
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