Follistatin 344 has a long and noteworthy history in the world of fitness and bodybuilding.
The peptide has been used for muscle gain and increasing strength, among other benefits.
As a result, Follistatin 344 promises to completely overhaul the appearance of your body as well as improve self-esteem and confidence.
Learn more about the purpose and benefits of Follistatin 344 in our complete review.
Table of Contents
What is Follistatin 344 Peptide?
Note: This is simply a review. Click Here to visit the official page of Follistatin-344 on the Core Peptides website.
Follistatin 344, sometimes abbreviated to “FST344”, is a naturally occurring peptide in the body.
Peptides are short chains of amino acids that serve as building blocks for proteins and other hormones.1
For this reason, peptides have been connected to a variety of health benefits, including gaining muscle and strength.
Follistatin 344, like many other peptides, has a unique ability to influence testosterone and other hormones essential to building lean muscle.
As such, Follistatin 344 has been utilized by weightlifters and fitness experts for decades.
Be that as it may, how the peptide was discovered actually has very little to do with building muscle.
In fact, the peptide was first discovered in the late-1980s for its role in secreting glycoprotein.
Glycoprotein is found in many tissues and organs, including the kidney, liver, and ovary.2
Furthermore, glycoprotein exists in bone marrow, blood vessels, and the pituitary gland (brain).
However, in 2001, scientists found another cause for Follistatin when it was first linked with muscle growth.3
Today, Follistatin 344 is readily used for men seeking to gain lean muscle and improve muscle mass.
How Does It Work?
Follistatin 344 is a recombinant form of follistatin, which naturally occurs in the body.4
The synthetic version is comprised of 323 amino acids along with a carbohydrate chain attached to its core.
The cellular composition of the peptide makes it capable of providing several different health benefits as a result (see, below).
Follistatin 344 follows several courses of action to trigger specific changes in the body.
First, the peptide offers a safeguard against uncontrolled cell production and cellular differentiation.
The peptide is produced by folliculostellate cells that exist in the anterior pituitary gland.5
These cells interact with many endocrine cells providing opportunities to heal and repair damaged tissues or cells.
Secondly, the peptide penetrates the bloodstream where it acts as an anti-inflammatory agent for wounds.
Follistatin assists with muscle growth through the inhibition of a compound known as myostatin.
Myostatin is a growth and differentiation factor protein that works against muscle growth.6
Therefore, Follistatin 344 inhibits the activin, which results in a decreased secretion of myostatin in the body.
Now, thanks to more follistatin (and less myostatin) the body is ready and prepared to stack on extra muscle.
Follistatin 344 Benefits
The first (and most obvious) benefit of Follistatin 344 is muscle growth.
Follistatin 344 has been used by athletes and bodybuilders for years seeking to improve body mass.
The results are generally impressive, however, the peptide also remains illegal which has kept it circulating underground.
Nonetheless, most men that have used Follistatin 344 in the past have reported a positive experience so long as they stick to the recommended dosage (see, below).
Follistatin 344 offers much hope for men seeking to improve muscle definition and overall mass.
The peptide is remarkable at producing more lean muscle and enhancing strength at the same time.
In fact, clinical studies are limited (more information, below) yet animal studies have displayed incredible results.
Additionally, Follistatin 344 has been linked to the following benefits:
- Impressive Muscle Gains
- Improved Strength & Endurance
- Improved Energy & Stamina
- Anti-Aging Treatment
- Weight Loss
- Hair Growth
Even better, Follistatin 344 may one day provide means to a cure for cancer.
While research is still very limited, there is some evidence that the peptide may ease symptoms related to some forms of cancer.7
Still, more conclusive studies are necessary to find a direct link between Follistatin 344 and cancer treatment.
How to Use Follistatin 344
Follistatin 344 is commonly available in powder and liquid form (see, Where to Buy?).
Often, users have to reconstitute the ingredients with bacteriostatic water.
It’s crucial that men follow the exact instructions provided with the packaging to ensure proper use.
Then, once the reconstituted protein is mixed, users must handle the ingredients with the right storage techniques.
Usually, this means keeping the mixture out of direct sunlight, away from extreme temperatures, and using the substance within 7-10 days.
In general, most experts suggest storing the contents in a refrigerator (even though storage at room temperature usually won’t lose potency).
Next, once the peptide is ready for consumption, users have the option of injecting intravenously or subcutaneously.
Since Follistatin 344 is not regulated by the FDA there are no approved or recommended dosage guidelines.
Be that as it may, most experts suggest a general dosage between 50 – 100mcg per day.
Moreover, users should not inject Follistatin 344 for longer than 10 – 30 consecutive days.
It’s also important that men follow proper cycling instructions and take a 3-4 week break before resuming the supplement.
The same is true for those seeking to stack Follistatin 344 with other muscle growth supplements.
Generally, the best advice is, to begin with a smaller dosage and witness how the body reacts.
You’ll find that users are divided online as to when and how Follistatin 344 is best administered.
Regardless, it’s highly advisable never to attempt and succeed 200mcg per day.
Weight Stacking
The new trend is to maximize time by stacking multiple supplements together for quicker results.
There is a wide variety of peptides and SARMS available for sale that complement each other when combined together.
For example, Follistatin 344 is often associated with other supplements like IGF-1 and Ostarine.
IGF-1 and IGF-DES are other, popular growth hormone supplements that maximize muscle growth.
On the other hand, ligandrol (LGD 4033) has been shown to improve lean muscle while also reducing recovery between workouts.
Additionally, Ostarine is another popular SARM that is often stacked with Follistatin 344.
The two muscle growth supplements work together to improve strength, power, and endurance.
Finally, GHRP-6 is effective when paired with Follistatin 344 at improving muscle mass and strength.
The growth hormone secretagogue (GHS) has also been associated with weight loss in the past.
Side Effects
In general, Follistatin 344 is considered safe to use when men follow the appropriate dosage and cycling instructions.
Still, information is limited and more research is necessary to determine how the peptide interacts with the body.
Currently, there are no dangerous or serious side effects that have been reported from Follistatin 344.
Nonetheless, side effects may include the weakening of joints and ligaments.
It’s also been shown to produce irritation and rashness at the injection site, which is pretty common with these types of supplements.
Lastly, some users have reported feeling flu-like symptoms during the first or second time injecting the substance.
However, these symptoms usually go away once the body adjusts to the new injection.
Nevertheless, any persisting or worsening symptoms should cause you to stop using the supplement.
Does It Really Work?
Follistatin 344 is misunderstood on many levels.
Unfortunately, not enough research has been dedicated to the subject leaving the outcome unpredictable.
The lack of human-based clinical trials makes the use of Follistatin 344 a little risky.
Be that as it may, there are multiple animal studies that have shown impressive results.
And, given the lack of other clinical research, it’s the only available information outside word-of-mouth sources.
Therefore, users must exercise caution with the peptide just like with any banned substance.
Still, what is known about the polyprotein is that it features a special ability to promote muscle growth.
Follistatin naturally occurs in the body and therefore carries some type of purpose.
The next challenge is getting more of the scientific community interested in the peptide and willing to devote time and attention to it.
Until then, most will have to rely on Internet sources for tips and instructions using Follistatin 344.
The peptide remains banned by the World Anti-Doping Association (WADA) yet continues to be used by many bodybuilders.
Proponents of Follistatin 344 allude to the numerous animal studies that have shown impressive results.8
In fact, the study concluded a 117% increase in muscle fibers in mice.
Meanwhile, other animal studies have been done on pigs and monkeys with equally comparable and impressive results.9 10
Even better, there is evidence to suggest that Follistatin 344 can prevent fibrosis.11
Today, human studies continue to lack yet clinical trials at the Phase I and Phase II level have thus far been encouraging.
The biggest challenge that remains is to understand how myostatin affects humans compared to other animal species, like monkeys and pigs.
Where to Buy?
It’s not always easy to find quality Follistatin 344 available for sale online.
Thankfully, CORE Peptides features one of the best sources for buying peptides online.
The company insists on producing its products at cGMP facilities and ensuring high testing standards.
Furthermore, customers receive free shipping on orders over $200 and the customer support is terrific.
For this reason, we suggest buying with CORE Peptides where you’ll always have a good shopping experience.
Visit their official page on Follistatin-344 here: www.CorePeptides.com/peptides/follistatin-344-1mg/
Conclusion
Follistatin 344 has a long history of improving lean muscle and muscle mass.
The muscle growth supplement has been used by athletes and bodybuilders for years.
Men can experience the benefits of Follistatin 344 by sticking to the suggested dosage and cycling instructions.
Follistatin 344 has the potential to completely change your body image and self-esteem.
References
- Wang L, Wang N, Zhang W, et al. Therapeutic peptides: current applications and future directions. Signal Transduct Target Ther. 2022;7(1):48. Published 2022 Feb 14. doi:10.1038/s41392-022-00904-4 (source)
- Brockhausen I, Schutzbach J, Kuhns W. Glycoproteins and their relationship to human disease. Acta Anat (Basel). 1998;161(1-4):36-78. doi:10.1159/000046450 (source)
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Lee SJ, McPherron AC. Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci U S A. 2001;98(16):9306-9311. doi:10.1073/pnas.151270098 (source)
- Zhu J, Li Y, Lu A, et al. Follistatin improves skeletal muscle healing after injury and disease through an interaction with muscle regeneration, angiogenesis, and fibrosis. Am J Pathol. 2011;179(2):915-930. doi:10.1016/j.ajpath.2011.04.008 (source)
- Marin F, Stefaneanu L, Kovacs K. Folliculostellate cells of the pituitary. Endocr Pathol. 1991;2(4):180-192. doi:10.1007/BF02915206 (source)
- Baig MH, Ahmad K, Moon JS, et al. Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies. Front Physiol. 2022;13:876078. Published 2022 Jun 23. doi:10.3389/fphys.2022.876078 (source)
- Sepporta MV, Tumminello FM, Flandina C, et al. Follistatin as potential therapeutic target in prostate cancer. Target Oncol. 2013;8(4):215-223. doi:10.1007/s11523-013-0268-7 (source)
- Rodino-Klapac LR, Haidet AM, Kota J, Handy C, Kaspar BK, Mendell JR. Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease. Muscle Nerve. 2009;39(3):283-296. doi:10.1002/mus.21244 (source)
- Chang F, Fang R, Wang M, et al. The transgenic expression of human follistatin-344 increases skeletal muscle mass in pigs. Transgenic Res. 2017;26(1):25-36. doi:10.1007/s11248-016-9985-x (source)
- VandeVoort CA, Mtango NR, Lee YS, Smith GW, Latham KE. Differential effects of follistatin on nonhuman primate oocyte maturation and pre-implantation embryo development in vitro. Biol Reprod. 2009;81(6):1139-1146. doi:10.1095/biolreprod.109.077198 (source)
- Mahdy MAA. Skeletal muscle fibrosis: an overview. Cell Tissue Res. 2019;375(3):575-588. doi:10.1007/s00441-018-2955-2 (source)
See Also
5 Best Peptides For Testosterone
6 Best Peptides For Weight Loss & Fat Burning
5 Best Peptides For Hair Growth
Born and raised in Woodbridge, NJ, he graduated from the New Jersey Institute Of Technology with an MBA in eCommerce.His hobbies include beach volleyball, target shooting, and lifting.
Rob is also a Commercially rated pilot and Certified Flight Instructor (CFI), with over 1,500 hours of flight time.
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