Have you heard all the rage about peptides like GHRP-2, Ipamorelin, CJC 1295, and Sermorelin?
These peptides offer much promise and hope for those seeking to lose weight, gain muscle mass, or reverse the signs of aging.
However, information is not always clear on the proper use or recommended dosage of peptides.
Learn more about the suggested dosage for GHRP-2, CJC 1295, Ipamorelin, and Sermorelin.
Table of Contents
GHRP 2 Dosage
Note: Click Here to pick up GHRP-2 from our #1 rated source, Core Peptides.
Growth Hormone Releasing Peptide-2 (GHRP-2) is a synthetic growth hormone secretagogue that stimulates natural production of the hormone.1
As a result, the peptide is associated with weight loss, increased muscle mass, and enhanced joint health / flexibility.2 3 4
For this reason, GHRP-2 is linked with improved athletic performance including substantial gains in lean muscle.5
Accordingly, GHRP-2 features a host of benefits including many anti-aging benefits.6
The “hunger hormone” is best administered via subcutaneous injection to the stomach or abdomen.
GHRP-2 is also available in oral or intranasal forms yet most experts consider subcutaneous injections the most effective route.
In general, most experts advise using a dosage between 150mcg – 300mcg, 1 – 3x per day.
Those seeking anti-aging treatment usually get by with a dosage between 150mcg – 200 mcg.
On the other hand, athletes and bodybuilders generally prefer a dosage of 300mcg or higher.
Regardless, the best results are witnessed when individuals avoid eating for at least an hour before using GHRP-2.
More importantly, new users should begin with a low dose and gradually increase / decrease the dosage depending on how the body responds.
How to Use
It’s crucial that new users reconstitute peptides after they receive the package / shipment.
Generally, peptides like GHRP-2 are shipped in a lyophilized powder substance.
Thus, the injectable forms of the treatment require reconstitution before they are effective.
Peptides are reconstituted by mixing the lyophilized powder with bacteriostatic water in a vial.
The vial is usually stored in a refrigerator for a predetermined amount of time before the powder dissolves into the liquid.
Furthermore, make sure that the syringe is clean and sterile (just like the vial) before administering GHRP-2.
In general, most prefer using GHRP-2 for 3 – 4 months before cycling off the peptide for 2 – 6 weeks.
Additionally, many have noticed better results when stacking GHRP-2 with other peptides like Ipamorelin, TB-500, and Sermorelin.
CJC 1295 Dosage
Note: This is just a review. Click Here to pick up CJC-1295 from our #1 rated source, Core Peptides.
CJC 1295 peptide is designed to produce rapid weight loss and lean muscle growth.7
It replicates the function of Growth Hormone-Releasing Hormone (GHRH) which assists in the release of Human Growth Hormone (HGH).8
CJC 1295 is often combined with other peptides like Ipamorelin for even better results.9
Thus, the amount of the dosage varies depending on whether the user is stacking CJC 1295 with other peptides or SARMs.
In general, experts recommend sticking to a dosage between 30 – 150mcg per injection.
Moreover, those who have experimented with CJC 1295 suggest taking the peptide 1 – 2 hours before waking up or going to bed.
Doing so will ensure that the peptide is best absorbed in the stomach and most likely to produce results.
It’s not necessary to administer CJC 1295 daily because the substance carries a longer half-life.
Furthermore, after finishing a 2 – 8 week cycle, users should take a 1 – 2 month break from CJC 1295 and other peptides.
Meanwhile, those seeking serious strength gains may attempt to expand the cycle length to 3 – 4 months.
CJC 1295 is also available in tablet / capsule form if the user prefers that method of consumption.
Nonetheless, most consider injections the most potent and effective method to achieving results.
How to Use
Unfortunately, concrete guidelines do not exist for the proper use of CJC 1295.
The dosage guidelines are recommended by athletes, bodybuilders, and fitness experts all of whom have found different pathways toward success.
Nevertheless, making sure not to exceed 300mcg per week will help individuals see results without jeopardizing health or causing unwanted side effects.
Be that as it may, most agree that CJC 1295 is most effective when combined with other supplements like Ipamorelin.
New users must take the time to exercise Post Cycle Therapy (PCT) following a CJC 1295 cycle.
Furthermore, make sure to store the peptides in a safe, cool location that is out of direct sunlight.
The formula is generally effective for 1 – 3 months and best preserved in a refrigerator after reconstitution.
Note: Click Here to pick up Ipamorelin from our #1 rated source, Core Peptides.
Ipamorelin is a high-quality peptide that provides a wide range of health benefits.
The peptide is associated with stronger bones, improved strength and muscle mass, and faster recovery from injury.10 11 12
Often, Ipamorelin is paired with other peptides to complement each other in a weight stack.
For example, since CJC 1295 is considered slow-acting, Ipamorelin compliments the peptide due to its reputation for expediating results.
Still, there are certain aspects of the peptide that separate Ipamorelin from others, like Sermorelin.
More importantly, determining the appropriate dosage varies significantly depending on what else and how much an individual is consuming.
Furthermore, it’s impossible to predict how Ipamorelin and other peptides will react with other prescribed medications.
Thus, speaking with a physician is critical for those who live with diseases or preexisting conditions.
However, for best results, make sure to administer Ipamorelin in the morning and with an empty stomach.
Some also divide the daily dosage into 2 separate administrations (morning and evening before bed).
All in all, most experts advise sticking to a low dosage between 3mcg – 10mcg (daily).
How to Use
The suggested amount of Ipamorelin depends on the user and what they seek to achieve.
Ipamorelin is available for sale orally, subcutaneously, and intravenously.
The method of consumption usually depends on personal preference yet injections are considered the most effective.
New users should inject Ipamorelin in a muscle group such as the buttocks or thigh.
It’s imperative that the user avoid striking a nerve or blood vessel with the needle to avoid injury.
Customers who decide to buy Ipamorelin in powder form must reconstitute the substance, just like with other peptides.
However, unlike other reconstituted substances, the formula doesn’t need to be refrigerated so long as it’s kept in a cool, dark location.
Ipamorelin traditionally produces noticeable results within 30 minutes of administration.
It’s okay to take the injection with food or water if you find your stomach is not sensitive to it.
Note: Click Here to pick up Sermorelin from our #1 rated source, Core Peptides.
There are numerous health benefits to the top-selling peptide Sermorelin.13
For starters, most consider the peptide among the best for healing, recovery, and repair from critical wounds and injuries.
Moreover, Sermorelin is even more effective when stacked with other supplements like GHRP-2 and Ipamorelin.
Accordingly, with proper care and use, Sermorelin benefits men and women of all ages.
Those benefits include:
- Improved cognitive function14
- Better vision15
- Enhanced immune system16
- Improved cardiovascular function17
- Improve bone health18
The best method of administration and dosage amount varies depending on the needs of the individual.
Furthermore, the individual should take an honest look at their health / medical situation before establishing a regimen.
In general, many prefer intramuscular injections so long as they exercise care avoiding tissue damage.
The Sermorelin oral capsules may be a more comfortable method yet require holding the dose under the tongue (1+ minute) for maximum consumption.
In the end, the suggested dosage fluctuates depending on age, health condition, experience using peptides, and many other factors.
How to Use
There are general guidelines for the use of Sermorelin that are applicable to just about any peptide.
First, it’s suggested that users take Sermorelin approximately 30 minutes before bedtime.
It ensures that the supplement is being absorbed into the body and can begin work while you rest.
Sermorelin should be administered on an empty stomach with nothing consumed 1 – 2 hours before taking the peptide.
It has a long shelf-life so long as the peptide is stored in a safe, cool, dry location away from direct sunlight.
Additionally, make sure that peptides are stored out of reach of children and household pets.
Sermorelin takes some time to produce results (2 – 3 months) so do not be discouraged if the body does not immediately improve.
It’s the primary reason why many decide to stack Sermorelin with other peptides and SARMs like Ipamorelin.
Weight stacking is a popular method for achieving faster, stronger results yet requires users to adjust the dosage amounts.
Accordingly, the proper dosage of Sermorelin varies depending on whether the substance is combined with others like TB-500, Ipamorelin, and GHRP-2.
Click Here to read our comprehensive review of Sermorelin.
What is the best dosage for peptides like Ipamorelin, GHRP-2, CJC 1295, and Sermorelin?
In general, there are no universal guidelines for dosage since many of these peptides are not regulated by the FDA.
Regardless, you can learn much about proper usage from experts online who have experimented with peptides.
Therefore, these guidelines serve as a decent benchmark for determining what works best for you.
- Laferrère B, Abraham C, Russell CD, Bowers CY. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005;90(2):611-614. doi:10.1210/jc.2004-1719 (source)
- Laferrère B, Hart AB, Bowers CY. Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake. Obesity (Silver Spring). 2006;14(6):1056-1063. doi:10.1038/oby.2006.121 (source)
- Hu R, Wang Z, Peng Q, et al. Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation. PLoS One. 2016;11(2):e0149461. Published 2016 Feb 19. doi:10.1371/journal.pone.0149461 (source)
- Granado M, Priego T, Martín AI, Villanúa MA, López-Calderón A. Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. Am J Physiol Endocrinol Metab. 2005;288(3):E486-E492. doi:10.1152/ajpendo.00196.2004 (source)
- Haruta I, Fuku Y, Kinoshita K, et al. One-year intranasal application of growth hormone releasing peptide-2 improves body weight and hypoglycemia in a severely emaciated anorexia nervosa patient. J Cachexia Sarcopenia Muscle. 2015;6(3):237-241. doi:10.1002/jcsm.12028 (source)
- Alba M, Fintini D, Bowers CY, Parlow AF, Salvatori R. Effects of long-term treatment with growth hormone-releasing peptide-2 in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2005;289(5):E762-E767. doi:10.1152/ajpendo.00203.2005 (source)
- Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. doi:10.1210/jc.2005-1536 (source)
Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006;91(12):4792-4797. doi:10.1210/jc.2006-1702 (source)
- Alba M, Fintini D, Sagazio A, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. doi:10.1152/ajpendo.00201.2006 (source)
- Svensson J, Lall S, Dickson SL, et al. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. J Endocrinol. 2000;165(3):569-577. doi:10.1677/joe.0.1650569 (source)
- Sinha DK, Balasubramanian A, Tatem AJ, et al. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020;9(Suppl 2):S149-S159. doi:10.21037/tau.2019.11.30 (source)
- Pountos I, Panteli M, Lampropoulos A, Jones E, Calori GM, Giannoudis PV. The role of peptides in bone healing and regeneration: a systematic review. BMC Med. 2016;14:103. Published 2016 Jul 11. doi:10.1186/s12916-016-0646-y (source)
- Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?. Clin Interv Aging. 2006;1(4):307-308. doi:10.2147/ciia.2006.1.4.307 (source)
- Garcia JM, Merriam GR, Kargi AY. Growth Hormone in Aging. [Updated 2019 Oct 7]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. (source)
- Cen LP, Ng TK, Liang JJ, et al. Agonist of growth hormone-releasing hormone enhances retinal ganglion cell protection induced by macrophages after optic nerve injury. Proc Natl Acad Sci U S A. 2021;118(28):e1920834118. doi:10.1073/pnas.1920834118 (source)
- Chang Y, Huang R, Zhai Y, et al. A potentially effective drug for patients with recurrent glioma: sermorelin. Ann Transl Med. 2021;9(5):406. doi:10.21037/atm-20-6561 (source)
- Kanashiro-Takeuchi RM, Szalontay L, Schally AV, et al. New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget. 2015;6(12):9728-9739. doi:10.18632/oncotarget.3303 (source)
- Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999;12(2):139-157. doi:10.2165/00063030-199912020-00007 (source)
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