Hexarelin is a powerful peptide that offers incredible promise.
The highly selective agonist is utilized in science to stimulate natural growth hormone production.
As a result, Hexarelin is known to promote rapid fat loss as well as lean muscle growth.
It has earned the peptide a stellar reputation in the fitness world (even if the substance lacks FDA approval).
Hexarelin enhances natural growth hormone levels in a far safer and more effective manner compared to steroids and other performance-enhancing drugs.
The advantages of Hexarelin range from weight loss and muscle growth to improved flexibility and recovery time.
Learn more about the benefits of Hexarelin in our complete review of the peptide.
IMPORTANT: The below peptides are NOT intended for those under the age of 18. If you are under the age of 18, do NOT consider taking them under any circumstances whatsoever.
Table of Contents
What Is Hexarelin?
Note: Click Here to pick up Hexarelin from our #1 rated source, Core Peptides.
Hexarelin (also known as Examorelin) is a potent, synthetic peptide that acts as a highly selective agonist.
The peptide was developed by an Italian pharmaceutical company seeking to advance the rate of weight loss as well as stimulate lean muscle growth.
There is evidence to suggest Hexarelin is productive in both aspects while also offering several other noteworthy benefits.1
Hexarelin stimulates muscle growth by serving as a highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR).2
Accordingly, Hexarelin also increases the production of Insulin-like Growth Factor 1 (IGF-1) in the body.
These two natural processes assist in the development of new lean muscle while assisting in weight loss.
Furthermore, Hexarelin aids in the development of your strength and overall body composition.
Those that supplement Hexarelin note significant improvements in overall athletic performance while reducing recovery time between training sessions.
More importantly, the peptide may lead to an overall healthier lifestyle by improving tendon and ligament strength.
These improvements also contribute to enhanced flexibility as well as joint health.
Despite all the positive momentum, clinical research remains limited and Hexarelin has yet to receive FDA approval.
It’s not all that shocking considering that the federal government has failed to acknowledge other peptides as potential sources for muscle growth.
Nevertheless, Examorelin has reached phase II in clinical trials as a treatment for growth hormone deficiency.
How Does Hexarelin Work?
The human growth hormone is produced and released in the pituitary gland.3
Thus, Hexarelin functions by stimulating hormone signals in the brain.
It results in greater secretion of the natural growth hormone which is essential to weight loss and muscle gain.
Secondly, Hexarelin suppresses a hormone in the body known as somatostatin., or the growth hormone inhibiting hormone.4
Somatostatin is counterproductive to gaining lean muscle as it actually reduces natural growth hormone output.
Third, Hexarelin can bind as well as activate the growth hormone secretagogue receptor (similar to ghrelin).5
Even better, the peptide is considered more potent and stable compared to ghrelin.
Moreover, research indicates that Examorelin releases more GH compared to the growth hormone-releasing hormone (GHRH) in humans.6
Thus, users report “massive” increases in plasma GH levels even when taking Hexarelin at low doses.
Fourth, the distribution of growth hormone secretagogue in the heart and blood vessels indicates that Hexarelin may provide other cardiovascular and neuroendocrine benefits.7
However, conflicting reports exist regarding how much Hexarelin influences the insulin-like growth factor 1 (IGF-1).8
Lastly, the powerful peptide is not known to produce the same negative side effects as synthetic hGH – which may shut down growth hormone production altogether.
5 Benefits of Hexarelin
The reported benefits of Hexarelin are substantial:
- Stimulates Muscle Growth
- Rapid Weight Loss
- Improves Strength & Flexibility
- Faster Recovery
- Improves Sleep & Overall Well-Being
Let’s examine each benefit of Hexarelin in more detail:
#1. Lean Muscle Growth
You are not alone if you feel unhappy about your weight or body composition.
However, finding a safe and reliable supplement for gaining lean muscle is not always easy.
There are so many supplements on the market and some of them feature more harmful side effects than the condition it’s attempting to treat.
Fortunately, the initial research on Hexarelin is promising and many stand behind the peptide in the weight lifting community.
Hexarelin is known to stimulate natural growth hormone production which contributes to lean muscle growth.
The peptide serves as a highly selective agonist of the GHSR and Insulin-like Growth Factor 1 (IGF-1).
It also acts comparable to ghrelin in activating the growth hormone secretagogue receptor while suppressing inhibitors like somatostatin.
Those that use Hexarelin in fitness and bodybuilding notice impressive results in terms of muscle and strength gains.
#2. Fat Burning & Weight Loss
Building lean muscle is only possible by first removing unwanted fat.
It’s a dilemma that many of us struggle with while attempting to maintain healthy eating and exercise habits.
Fortunately, Hexarelin is capable of accelerating weight loss by targeting critical natural processes in the body.
The rapid fat loss effect can assist you in reaching your weight loss goals faster than ever.
More importantly, you’ll do so in a far more safe and effective manner compared to other harmful drugs or diet programs.
The combination of fat burning and lean muscle gains from Hexarelin can lead to a complete body overhaul.
#3. Improves Strength & Flexibility
While receiving a complete body makeover you also inherit the benefits of improved strength and flexibility.
Hexarelin is known to vastly improve tendon and ligament strength.
Additionally, the peptide is linked to enhanced flexibility and overall joint health.
It’s crucial to focus on tendons, ligaments, and muscles as you age because they are especially at risk for injury.
Consequently, you’ll achieve little if you are stuck on the sideline because of a lingering injury.
Hexarelin not only enables you to recover and hit the gym sooner but avoids serious injuries in the first place thanks to the gains in flexibility.
#4. Stronger Recovery & Athletic Performance
There are added benefits to losing weight, gaining lean muscle, and improving overall strength/flexibility.
For starters, you’ll recover faster which grants you the opportunity to return to the gym and get back to work.
Recovery is essential to weight loss and muscle gains, so finding supplements that aid in that process is vital.
Hexarelin is known to promote faster recovery from injuries and training.
It’s especially resistant to musculoskeletal injuries that hamper progress in the gym.
Moreover, you’ll witness overall improvements in athletic performance as a result.
#5. Improves Sleep Quality & Overall Well-Being
Another benefit to Hexarelin is testimonials regarding how the peptide improves overall sleep quality.
The enhancement of physical capability along with the traditional exertion of working out generally leads to peaceful nights.
And, since sleep is so essential to overall health, the peptide contributes to a stronger sense of well-being.
Losing weight and getting stronger leads to improved self-esteem and confidence.
You’ll not only sleep better but feel better thanks to the positive effects of Hexarelin.
Side Effects of Hexarelin
Thankfully, the reported side effects of Hexarelin are minimal.
The most common side effects include feelings of fatigue or lethargy.
It’s due to the ability of the growth hormone to also increase a desire for sleep.
However, keeping the dosage low can easily offset this issue.
Excess/high dosages of Hexarelin may contribute to water retention.
Another side effect that has been reported is tingling or numbness in the hands or feet.
Those that experience symptoms should lower the dosage or consider removing from supplementation altogether.
It’s best to speak with a physician before use if you already take other prescription medication.
Where To Buy Hexarelin
While there are dozens of peptides sources and suppliers, we highly recommend you go with a company called Core Peptides
They are by far the best peptides source online, and sell Hexarelin at reasonable prices.
Click Here to see their page on Hexarelin.
Conclusion
Hexarelin has the promise to serve as a game-changer in fitness and health.
Limited research indicates its effective at treating both weight loss as well as assisting in gaining lean muscle.
The other benefits of Hexarelin include improved strength and flexibility, faster recovery, and healthier sleep habits.
The potent peptide is capable of producing impressive results with the correct dosage and cycling.
It’s considered far safer compared to anabolic steroids and other performance-enhancing drugs (P.E.D.’s).
References / Resources
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Massoud AF, Hindmarsh PC, Matthews DR, Brook CG. The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity. Clin Endocrinol (Oxf). 1996;44(5):555-562. doi:10.1046/j.1365-2265.1996.722543.x (source)
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Bellone J, Bartolotta E, Sgattoni C, et al. Hexarelin, a synthetic GH-releasing peptide, is a powerful stimulus of GH secretion in pubertal children and in adults but not in prepubertal children and in elderly subjects. J Endocrinol Invest. 1998;21(8):494-500. doi:10.1007/BF03347334 (source)
- Nussey S, Whitehead S. Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers; 2001. Chapter 7, The pituitary gland. (source)
- O’Toole TJ, Sharma S. Physiology, Somatostatin. [Updated 2021 Jul 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. (source)
- Young ER, Jialal I. Biochemistry, Ghrelin. [Updated 2021 Jul 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. (source)
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Arvat E, di Vito L, Maccagno B, et al. Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man. Comparison with the effects of GHRH, TRH and hCRH. Peptides. 1997;18(6):885-891. doi:10.1016/s0196-9781(97)00016-8 (source)
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Mao Y, Tokudome T, Kishimoto I. The cardiovascular action of hexarelin. J Geriatr Cardiol. 2014;11(3):253-258. doi:10.11909/j.issn.1671-5411.2014.03.007 (source)
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Imbimbo BP, Mant T, Edwards M, et al. Growth hormone-releasing activity of hexarelin in humans. A dose-response study. Eur J Clin Pharmacol. 1994;46(5):421-425. doi:10.1007/BF00191904 (source)
See Also
Best Peptide Sources & Companies
8 Best Peptides For Muscle Growth
Born and raised in Woodbridge, NJ, he graduated from the New Jersey Institute Of Technology with an MBA in eCommerce.His hobbies include beach volleyball, target shooting, and lifting.
Rob is also a Commercially rated pilot and Certified Flight Instructor (CFI), with over 1,500 hours of flight time.
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