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Laxogenin Review (2022): Benefits, Side Effects, Dose, & More

Professional athletes and bodybuilders are frequently searching for the best methods to excel at their sport.

The human body is a complex system which makes it a constant struggle to maintain an ideal weight while also being proud of its composition.

In the past, athletes made the mistake of turning to harmful substances like steroids for gaining muscle mass and enhancing performance.

Thankfully, those days are in the past as athletes and bodybuilders are discovering a safer and more effective solution with Laxogenin.

Laxogenin is an extremely powerful and highly anabolic compound that is extracted from a plant.

For this reason, the potential to build lean muscle, increase energy and stamina, as well as improve recovery time exists because the compound enhances the rate of protein synthesis.

As a result, many athletes have switched to Laxogenin because they consider it a safer alternative to steroids and other muscle growth substances.

Learn more about Laxogenin in our complete review.

NOTE: The below supplements are NOT intended for those under the age of 18.  If you are under the age of 18, do NOT consider taking them under any circumstances whatsoever.

Also, if you’re planning on joining the military, cease using this (and really any) supplement at least a couple months before going to MEPS. 

They can cause a false positive on a drug test, and will affect your chances of joining!

What is Laxogenin?

laxogenin reviews

Note: Click Here to buy Laxogenin legally online from our #1 rated source, Behemoth Labz.

Laxogenin – officially defined as 5 alpha-hydroxy laxogenin – is a compound that is extracted from the Simalez Sieboldii plant.1

The substance has recently gained traction in the weightlifting and bodybuilding communities because it’s highly anabolic.

Therefore, the compound enhances the speed of protein synthesis which encourages the body to develop lean muscle, improve strength, and inherit faster recovery.

Laxogenin performs in the body comparable to steroids yet does not produce the same nasty side effects.

It’s precisely why Laxogenin has gained in popularity and, along with other weight stack supplements, is considered a safer and more effective means to lean muscle growth.

There are many benefits to why people of all body types and skill levels may want to consider adding Laxogenin to their weight stack:

  • Increases Lean Muscle
  • Improves Strength & Power
  • Improves Recovery Time
  • Burns Fat Reserves

Laxogenin is a member of a group of compounds called brassinosteroids.

Brassinosteroids are plant hormones that are very comparable to ecdysteroids or animal steroid hormones.2

These “plant steroids” are responsible for the regulation of genes and growth in plants.

However, it’s important not to confuse Laxogenin with prohormones as the two substances produce different mechanisms for production.3

Consequently, plant hormones like Laxogenin are considered safer compared to synthetic steroids which were used in the past to build muscle.4

Unfortunately, clinical research on Laxogenin remains limited as thus far studies have been restricted to animal experiments.

Thus, Laxogenin remains elusive and is not approved by the FDA much like other natural weight stack supplements.

While there is personal testimony to warrant the use of Laxogenin, users still need to retain caution since human research remains limited.

More Detailed Laxogenin Benefits

There is rich value in Laxogenin since the plant compound is highly anabolic.

Laxogenin functions by improving protein synthesis and therefore encouraging muscle growth.5

There are reports from satisfied customers that they were able to put on 10-15 lbs of lean muscle by using Laxogenin with other SARMs (more information, below).

Furthermore, the powerful plant hormone has the ability to burn fat reserves, lower cortisol, as well as enhance performance and recovery.

Additionally, the substance is currently being researched in animals as a form of treatment for cancer, diabetes, and tissue damage.

Nevertheless, Laxogenin is not a steroid or prohormone and therefore does not present the same awful side effects (more information, below).

The manufacturers of the plant hormone consider it well-tolerated as no serious side effects have currently been reported.

Let’s review the benefits of Laxogenin in more detail:

Builds Lean Muscle

Laxogenin encourages lean muscle growth because the plant compound is highly anabolic.

Plant steroids function through a separate pathway from that of human steroid hormones.

Consequently, plant steroids only attach to the surface of the cell and deliver signals to develop muscle tissue.6

The protein synthesis is achieved by activating a protein known as AKT1.7

The plant protein AKT1 assists with building lean muscle as well as preventing the breakdown of proteins crucial to muscle tissue growth.8

For this reason, Laxogenin can help you bulk up quickly as many users report lean muscle increases of 10-15 lbs (especially when “stacked” with SARMs).

Improves Strength & Power

Laxogenin compliments selective androgen receptor modulators (SARMs) in weight stacks designed to increase strength and power.

First, the plant compound prevents enzymes that break down cAMP which helps burn excess fat reserves.9

Secondly, with the fat storage burned off, the substance activates an anabolic protein which triggers the fight-or-flight (sympathetic) response.10

The fight-or-flight response is vital to improving physical performance at the gym.

Therefore, users of Laxogenin may notice increased strength, power, and energy levels.11

Improves Recovery

Laxogenin not only helps users achieve peak levels of performance at the gym but improves the time spent between workout sessions.

The fight-or-flight response is triggered to stimulate protein synthesis for energy necessary to build lean muscle.

However, there are far too many muscle growth supplements that present you with a boost of energy followed by a terrible crash.

Laxogenin aims to do the opposite and improve recovery time so you can hit the gym sooner.

Prevents Estrogen Conversion

Steroids earned a horrible reputation partly because of how it fluctuates levels of estrogen.

It would explain why some of the awful side effects of steroids in men include developing man breasts.

However, Laxogenin does not produce the same estrogen conversion as conventional human steroids.

Thus, the plant compound is not known to convert into more powerful male sex hormones (i.e. testosterone) or run the risk of elevating estrogen in men.

It’s one of the many reasons bodybuilders consider Laxogenin and SARMs safer compared to synthetic steroids.

Laxogenin Dosage and Cycle Instructions

There are a few different opinions on the proper dosage for Laxogenin.

Nonetheless, most believe the optimal dosage exists between 100-200mg per day.

For this reason, experts suggest beginning with a dose of 100mg per day and note any improvements.

The lower starting dose will also allow you to monitor any potential side effects as your body adjusts to the herbal remedy (and other supplements of your weight stack).

Then, users may want to consider increasing the daily dosage to 200mg per day for optimal results.

There are also different opinions on how long to cycle Laxogenin with most reaching a conclusion between 4-12 weeks.

Most users aim for cycles of 10-12 weeks as the longer you take it – the stronger the results.

Be that as it may, it’s crucial not to use Laxogenin for more than 12 weeks.

Furthermore, allow a 4-week break before starting another cycle.

Lastly, there are varying opinions on whether you need Post Cycle Therapy (PCT) following Laxogenin.

You’ll likely need to experiment a little to find the best weight stack and cycle for gaining lean muscle (or, see our recommendations, below).

Laxogenin can take anywhere from a few days to 2 weeks to notice results.

What the Research Says About Laxogenin

Unfortunately, there is limited clinical research regarding Laxogenin.

Moreover, it’s easy to fall for a scam as many supplements advertised with Laxogenin actually do not contain it but the synthetic derivative – laxosterone.

Notwithstanding, the efficacy of Laxogenin is limited to a few animal and cell studies.

Thus, the plant compound has not been thoroughly examined in clinical trials and therefore is not approved by the FDA.

Still, there is hope and potential for Laxogenin to build lean muscle by activating the plant protein AKT1.

The good news is that Laxogenin is not a steroid or prohormone and does not produce a known estrogen conversion or side effects.

Laxogenin Reviews

There is not a lot of clinical information available for Laxogenin.

Consequently, the plant compound is a product of being blacklisted despite producing promising indications that it can stimulate muscle growth.

Thus, a lot of the support for Laxogenin remains underground as mainstream support is growing.

With that said, I did find this rather informative Laxogenin review from a gentleman on Youtube: 

Laxogenin Side Effects

For starters, it’s important to note that Laxogenin has not been fully studied in clinical studies.

Therefore, most of the side effects of Laxogenin are reports made by users.

Thus, not everything is known about Laxogenin and how it interacts with the human body.

Nonetheless, personal testimonials have thus far been positive and no serious side effects have been reported.

As a result, Laxogenin and SARMs are generally considered safer and more effective for weight gain and muscle growth compared to steroids.

Laxogenin was safe in animal studies yet has not fully been tested in humans in a clinical setting.

Most users claim to not notice any serious side effects at the suggested dose of 200mg per day.

There were a few claims about minor side effects like headaches or nausea.

Meanwhile, others noticed an upset stomach that went away as the body became more accustomed to the plant compound.

Thus, we feel confident that as long as you do not go overboard with dosage or cycle length, you’ll feel just fine.

Still, Laxogenin is not recommended for those that suffer from kidney disorders or certain prescribed medications.

We suggest speaking with a physician prior to starting Laxogenin or any other supplement for muscle gain.

Laxogenin With Other SARMS

Laxogenin is commonly “stacked” with other supplements designed to improve energy, strength, and muscle growth.

For starters, you need to understand that Laxogenin is not a prohormone (despite claims that state the opposite).

Rather, the substance targets different pathways compared to human steroids that affect nuclear receptors such as testosterone and estrogen levels.

Brassinosteroids like Laxogenin clearly increase growth in plants so the hope is that they can do the same in the human body by stimulating protein synthesis.

Consequently, Laxogenin is often included with other SARMs in the best weight stacks for gaining lean muscle:

Stacking Laxogenin and RAD 140

laxogenin and rad-140 stack

There is little question that RAD 140 Testolone is one of the best SARMs to stack with Laxogenin.

The powerful selective androgen receptor modulator (SARM) is popular among athletes and bodybuilders.

The therapeutic compounds promote anabolic cell activity and therefore avoid the common side effects of traditional steroids.

RAD 140 Testolone increases muscle growth by focusing on testosterone levels.

Thus, you inherit an energy and power booster that can also assist with fat reduction.

The end result is noticeable improvements in body composition as well as brain function.

If you are seeking the most powerful SARM then you’ll struggle to find one with more satisfying personal testimonials than RAD 140.

It’s widely considered more powerful compared to other SARMs like LGD-4033 and MK-2866 Ostarine.

You can pick both of these up on the Behemoth Labz website, here’s links for each:

Stacking Laxogenin and 4-Andro

laxogenin and 4andro stack

4-Andro is another worthwhile consideration to pair with Laxogenin for a muscle growth weight stack.

The 2-Step Testosterone Conversion is possible thanks to the assistance of DHEA.

Thus, the anabolic agent functions differently from its dry bulking agent cousin: 1-Andro.

For this reason, 4-Andro performs best as a testosterone converter when stacked with other suppressive chemicals like RAD 140, S-23, and LGD-4033.

The recommended daily serving is 75mg for improved strength and enhanced recovery.

You can pick both of these up on the Behemoth Labz website, here’s links for each:

Stacking Laxogenin, MK-677, YK11

laxogenin yk11 and mk677 stack

You may stack Laxogenin with multiple other supplements including MK-677 and YK11.

Ibutamoren (MK-677) is a growth hormone secretagogue that increases human growth production.

MK-677 also increases IGF-1 levels while reducing recovery time between workouts.

The daily dosage recommendation is 30mg with a cycle that lasts between 12-24 weeks.

Meanwhile, MK-677 stacks well with Myostine (YK11).

Myostine (YK11) facilitates muscle growth as well as increases follistatin in the body.

Thus, the neuroprotective agent can increase muscle tissue and power as it repairs aging cells.

YK11 is well-tolerated and safe at the low daily dose of 10mg.

Lastly, you may want to consider other options to stack with Laxogenin. Here’s links to each:

Where To Buy Laxogenin

Laxogenin is available from reputable suppliers like

We suggest purchasing through a reliable manufacturer as there are plenty of scams related to the substance.

Behemoth Labz offers a fully secure checkout process and free shipping on orders over $100.

Moreover, all purchases made through the supplier come with a 60-day money-back guarantee.

Laxogenin is available in a bottle that contains (90 capsules) that will last 2-3 months depending on daily dosage.

Each capsule offers 100mg of the plant compound with the recommended daily dose between 100-200mg.

The substance is currently available in capsules with the following flavors: Sour Apple, Strawberry Lemonade, Elderberry.


There is so much hope and potential for Laxogenin.

While we do wish the substance would receive more research and focus from clinical studies, the initial evidence is promising.

The anabolic agent can help burn fat, build lean muscle, improve strength, and enhance recovery time between workouts.

Laxogenin can offer many of the benefits of traditional synthetic steroids but without the awful side effects.

However, it’s crucial that you purchase Laxogenin from a reputable manufacturer to avoid consuming the synthetic derivative – laxosterone.

The most effective way to take the anabolic agent is in a weight stack with selective androgen receptor modulators (SARMs) and other supplements.


  1. Cohen PA, Sharfstein J, Kamugisha A, Vanhee C. Analysis of Ingredients of Supplements in the National Institutes of Health Supplement Database Marketed as Containing a Novel Alternative to Anabolic Steroids. JAMA Netw Open. 2020;3(4):e202818. Published 2020 Apr 1. doi:10.1001/jamanetworkopen.2020.2818 (source)
  2. Nolan TM, Vukašinović N, Liu D, Russinova E, Yin Y. Brassinosteroids: Multidimensional Regulators of Plant Growth, Development, and Stress Responses. Plant Cell. 2020;32(2):295-318. doi:10.1105/tpc.19.00335 (source)
  3. Ziegenfuss TN, Berardi JM, Lowery LM. Effects of prohormone supplementation in humans: a review. Can J Appl Physiol. 2002;27(6):628-646. doi:10.1139/h02-037 (source)
  4. Esposito D, Komarnytsky S, Shapses S, Raskin I. Anabolic effect of plant brassinosteroid. FASEB J. 2011;25(10):3708-3719. doi:10.1096/fj.11-181271 (source)
  5. Avula B, Chittiboyina AG, Bae JY, et al. The power of hyphenated chromatography-Time of flight mass spectrometry for unequivocal identification of spirostanes in bodybuilding dietary supplements. J Pharm Biomed Anal. 2019;167:74-82. doi:10.1016/j.jpba.2018.12.045 (source)
  6. Deng Y, Wang J, Zhang A, et al. Metabolomics Mechanism and Lignin Response to Laxogenin C, a Natural Regulator of Plants Growth. Int J Mol Sci. 2022;23(6):2990. Published 2022 Mar 10. doi:10.3390/ijms23062990 (source)
  7. Esposito D, Rathinasabapathy T, Poulev A, Komarnytsky S, Raskin I. Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J Med Chem. 2011;54(12):4057-4066. doi:10.1021/jm200028h (source)
  8. Hajduch E, Alessi DR, Hemmings BA, Hundal HS. Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes. 1998;47(7):1006-1013. doi:10.2337/diabetes.47.7.1006 (source)
  9. Kubo S, Mimaki Y, Sashida Y, Nikaido T, Ohmoto T. Steroidal saponins from the rhizomes of Smilax sieboldii. Phytochemistry. 1992;31(7):2445-2450. doi:10.1016/0031-9422(92)83296-b (source)
  10. Hursel R, Westerterp-Plantenga MS. Thermogenic ingredients and body weight regulation. Int J Obes (Lond). 2010;34(4):659-669. doi:10.1038/ijo.2009.299 (source)
  11. Pacheco DF, González Ceballos L, Castro AZ, et al. Synthesis of New Steroidal Carbamates with Plant-Growth-Promoting Activity: Theoretical and Experimental Evidence. Int J Mol Sci. 2021;22(5):2330. Published 2021 Feb 26. doi:10.3390/ijms22052330 (source)

See Also 

Best SARMS For Bulking & Cutting

Best Supplement Stacks For Muscle Gain

Best Fat Burning Supplement Stacks For Cutting


Rob V.


4.7 out of 5 (33 Ratings)

Learn more about Laxogenin in our comprehensive review of the benefits, side effects, before and after results, where to buy it, and much more.
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