Resistance to infections costs the U.S. health care industry more than $4.5 billion a year.
LL 37 peptide is designed to reverse the challenges medical experts face in terms of Antimicrobial Resistance (AMR).
The issue is one of the biggest dilemmas that the industry faces when once-effective drugs suddenly stop working against pathogens.
However, this peptide offers promise as an effective form of antimicrobial treatment.
For this reason, the petide is designed to treat fungal infections, viral infections, and bacterial infections.
Learn more about LL 37 peptide in our complete review.
IMPORTANT: The below peptides are NOT intended for those under the age of 18. If you are under the age of 18, do NOT consider taking them under any circumstances whatsoever.
Table of Contents
What Is LL-37 Peptide?
Note: Click Here to pick up LL-37 from our #1 rated source, Core Peptides.
LL 37 is a peptide that features 37 amino acids derived from the C-terminal of a larger protein in your body known as cathelicidin.1
Cathelicidin (hCAP18) exists as the only naturally-produced human cathelicidin in existence.2
The compound is found in multiple parts of the body and produces an amino acid sequence that begins with 2 leucines (hence the double L).
LL 37 peptide is tasked with eliminating foreign micro-organisms through membrane disruption.3
Nevertheless, the petide is not simply a bacteria-fighting peptide.4
Rather, the peptide is capable of treating allergic rhinitis in children as well as bronchiolitis.5
The peptide was created in the mid-1990s to examine Antimicrobial Resistance (AMR).
As a result, its primary function is to treat microbial infections, especially infections caused by antibiotic-resistant pathogens.6
LL 37 peptide features several advantages over conventional antibiotics including lower levels of resistance and rapid killing of dangerous bacteria.7
In the end, the peptide is one of the best candidates to overcome antibiotic resistance.
Benefits of LL-37 Peptide
There are numerous benefits to using LL 37 peptide.
For starters, the antimicrobial peptide (AMP) is one of the best alternatives to antibiotics.
The peptide fights infections and diseases at its source because it fights bugs, regulates bacterial invasions, and controls infections.
Moreover, the peptide is known to reduce inflammation in patients as well.
It has also demonstrated healing properties to damaged tissue (arthritis, Lupus, etc.).
Therefore, the peptide serves as the first line of defense for the body in regard to injuries, wounds, infections, and inflammation.
The peptide is known to treat tick-borne illnesses such as RMSF, Babesiosis, and Colorado Tick Fever.
Additionally, the peptide has been linked to treating E. Coli, diabetes, and certain types of cancer.
The top benefits of LL 37 peptide include:
- Alternative to Antibiotics
- Reduces Antifungal Effects
- Reduces Antiviral Effects
- Treats Issues with Stomach/Gut
- Faster Recovery from Wounds/Injuries
LL 37 is a fantastic alternative to traditional antibiotics in regards to bacterial infections and diseases.
How Does LL-37 Peptide Work?
LL 37 peptide is designed to treat the results of Antimicrobial Resistance (AMR).
Antimicrobial Resistance occurs when bacteria, viruses, fungi, and parasites evolve over time and no longer respond to medication that treated the issue in the past.
Consequently, it makes these types of infections harder to treat since the infection has become more resistant.
Furthermore, infection resistance can lead to the spread of the disease, severity, or even death.
As a result, the peptide seeks to combat this issue by targeting the pathogen at its core.
LL 37 peptide is believed to disrupt the bacterial membrane of the invader in the body.
Nonetheless, LL 37 does not operate like your traditional agonist, especially in terms of disrupting the membrane.
Rather, the peptide remains parallel to the membrane as opposed to being directly inserted into it.
LL 37 peptide belongs to a family known as cathelicidin peptides.
These tiny peptides exist in a variety of functions from the cells to the skin to the lungs.
Furthermore, the peptide naturally occurs in the mouth, tongue, and esophagus.
It has been noted that the peptide is especially beneficial when combined with vitamin D.
Ultimately, the peptide provides an integral role in defending the body against infection and disease.
Moreover, the peptide is also instrumental in recovering from injuries and wounds.
Lastly, the peptide provides an indirect role in the immune response to foreign antigens.8
The below Youtube video goes into pretty good detail about how it works:
Side Effects of LL-37 Peptide
There is limited data in terms of the side effects associated with the LL 37 peptide.
It’s largely due to the U.S. Food and Drug Administration (FDA) refusing to acknowledge peptides as legitimate medicine.
Nevertheless, the side effects of the peptide remain not serious or damaging to health.
In accordance, the majority of side effects are related to the peptide being ineffective or unable to resist the infection.
However, that’s not an awful by-product of something the peptide is attempting to treat.
Overall, there are not any serious or dangerous side effects to report with LL 37 peptide use.
How To Use LL-37 Peptide
There is no “set” dosage for using LL 37 peptide.
Instead, users should refer to manufacturer guidelines or doctor recommendations.
The dose varies depending on the infection/disease you are treating as well as severity.
There are suggestions to start with 100mcg per day.
Injections usually last for 1-3 months depending on the treatment.
Furthermore, LL 37 use is generally followed by a 2-4 week cycle away from the peptide.
Users may increase the dosage after introducing the body to the peptide.
In the end, the peptide remains “experimental” and outside the boundaries of FDA approval.
Tips for Using Peptides
The human body contains trillions of microorganisms that outnumber cells by 10 to 1, according to the National Institute of Health.
Although some microorganisms are essential to humans others contain harmful bacteria (viruses, fungi, parasites, etc.).
The peptide is designed to reverse the devastating trends caused by viral infections and diseases.
The peptide targets the issue at its source and seeks to reverse symptoms as a result.
Unfortunately, since LL 37 peptide remains outside FDA regulation, there is still much to learn about the substance.
Notwithstanding, support for the peptide is stellar because of its untapped potential.
It’s recommended to follow dosage guidelines as well as proper storage advice.
Peptides provide ultimate promise yet need to get used properly to avoid mislabeling or misconceptions.
Stacking With Other Peptides
It’s common to “stack” LL 37 with other peptides.
Stacking offers several benefits including the ability to witness results sooner.
It’s especially important when dealing with the adverse symptoms of a virus, infection, or disease.
There are many insiders that suggest stacking it with TB-500.
Meanwhile, others recommend pairing the peptide with vitamin D.
As a result, make sure you are getting 20-30 minutes of direct sunlight each day or supplementing to explore the full benefits of LL 37.
Does LL-37 Peptide Work?
LL 37 is naturally produced within the body through various tissue and circulation.
The peptide is found in bone marrow cells, epithelial cells, and gastrointestinal cells.
Regardless, the body is short of this crucial peptide and relies on other sources to survive.
Consequently, the area of your body is vulnerable to bad bacteria which leads to pathogens accumulating and chronic disease.
Meanwhile, peptides seek to combat this issue by releasing certain proteins that focus on refining bodily functions as opposed to damaging them.
The peptide has been proven effective to treat the following conditions:
- Antiviral & Antifungal Activity
- Bacterial Invasions
- Respiratory Syncytial Virus
- Contraceptive Therapy
- Gastrointestinal Issues
- Skin & Wound Healing
- Cancer (Certain Conditions)
The compound has demonstrated a rare ability to fight cancer in the stomach/gut.9
Colorectal and gastric adenomas play a role in the down-regulation of cathelicidins.
Accordingly, the peptide is receiving more focus in medical research moving forward.
It’s crucial to understand LL 37 because it has the potential to treat serious infectious diseases and infections.
Where To Buy LL-37
We recommend that you pick up LL-37 from a company called Core Peptides.
They are a market leader in the peptides niche, and produce high quality products.
Click Here to see their page on LL-37.
The compound is available and suggested for those suffering from a viral infection.
The peptide is designed to replicate AMPs in that it deals with devastating viruses and infections.
Its quest is necessary for medical research to attain the knowledge necessary to achieve an alternative perspective on the peptide.
AMPs provide the potential to regulate bacteria/virus infections yet demand more research.
Until then, consider LL 37 peptide for your needs.
Shi Y, Li C, Wang M, et al. Cathelicidin-DM is an Antimicrobial Peptide from Duttaphrynus melanostictus and Has Wound-Healing Therapeutic Potential. ACS Omega. 2020;5(16):9301-9310. Published 2020 Apr 14. doi:10.1021/acsomega.0c00189 (source)
Kościuczuk EM, Lisowski P, Jarczak J, et al. Cathelicidins: family of antimicrobial peptides. A review. Mol Biol Rep. 2012;39(12):10957-10970. doi:10.1007/s11033-012-1997-x (source)
Kahlenberg JM, Kaplan MJ. Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J Immunol. 2013;191(10):4895-4901. doi:10.4049/jimmunol.1302005 (source)
Pahar B, Madonna S, Das A, Albanesi C, Girolomoni G. Immunomodulatory Role of the Antimicrobial LL-37 Peptide in Autoimmune Diseases and Viral Infections. Vaccines (Basel). 2020;8(3):517. Published 2020 Sep 10. doi:10.3390/vaccines8030517 (source)
Gordon YJ, Huang LC, Romanowski EG, Yates KA, Proske RJ, McDermott AM. Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity. Curr Eye Res. 2005;30(5):385-394. doi:10.1080/02713680590934111 (source)
Ridyard KE, Overhage J. The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent. Antibiotics (Basel). 2021;10(6):650. Published 2021 May 29. doi:10.3390/antibiotics10060650 (source)
Nagaoka I, Tamura H, Reich J. Therapeutic Potential of Cathelicidin Peptide LL-37, an Antimicrobial Agent, in a Murine Sepsis Model. Int J Mol Sci. 2020;21(17):5973. Published 2020 Aug 19. doi:10.3390/ijms21175973 (source)
Alalwani SM, Sierigk J, Herr C, et al. The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils. Eur J Immunol. 2010;40(4):1118-1126. doi:10.1002/eji.200939275 (source)
Kuroda K, Okumura K, Isogai H, Isogai E. The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs. Front Oncol. 2015;5:144. Published 2015 Jun 30. doi:10.3389/fonc.2015.00144 (source)
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