The goal of working out is simple – to build lean muscle and bulk up.
However, many people find it challenging to achieve the ripped physique that they want despite hours at the gym, eating nutritious food, and doing everything else right.
If you’ve experienced challenges building your lean muscle mass, you might be interested in the benefits that modern drugs can offer.
In this review, we’ll explore S23 SARM and what it might offer you. SARMs come in many different forms, such as Ligandrol.
However, S23 offers some important differences from other SARMs and may be a better fit for your needs.
NOTE: The below supplements are NOT intended for those under the age of 18. If you are under the age of 18, do NOT consider taking them under any circumstances whatsoever.
Also, if you’re planning on joining the military, cease using this (and really any) supplement at least a couple months before going to MEPS.
They can cause a false positive on a drug test, and will affect your chances of joining!
Table of Contents
What Is S23 SARM?
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S23 is a SARM – a selective androgen receptor modulator.
It is a lab-created drug that is being tested to help patients struggling with muscle wasting and bone loss.1
However, those same benefits can do a world of good for bodybuilders and athletes who want to build lean muscle mass but have been struggling to maximize their gains.
In a nutshell, this drug binds with your body’s androgen receptors (both men and women) and changes how muscle and bone tissue behave.
It is proven to accelerate the growth and repair of lean muscle tissue and even bone, allowing it to be used in therapeutic settings for individuals suffering from age and disease-related muscle and bone loss.
It even has the potential to enhance sexual motivation in females, although the science is not conclusive on that.2
However, S23 SARM is not without its drawbacks. It carries the risk of serious side effects, including liver damage, heart attack, and stroke.3
It is also a banned substance on the World Anti-Doping Agency’s list, and any competitive athlete (pro or amateur) who tests positive for its use can be blocked from competing for several years.
In addition to its use in the therapeutic treatment of muscle and bone density loss, S23 SARM is also being studied for many other uses.
One of the most interesting is its potential use as a male contraceptive, due to its ability to suppress testosterone and sperm production.
A study conducted on lab rats was able to create 100% infertility in male test subjects.4
Note that this was reversed after the rats were no longer given S23 SARM.
However, there have been no long-term studies on the impact of taking S23 SARM over prolonged periods.
How Does S23 SARM Differ from Others on the Market?
As mentioned, S23 SARM is not the only one of its kind on the market. Many other SARMs are manufactured and sold as experimental products.
However, S23 is unique from other options in several key ways, including the following:
- It offers up to 96% bioavailability, which is substantially more than other SARMs.
- It shows one of the highest binding affinities of any SARM on the market and is comparable to LGD-4033 (Ligandrol).
- It is comparable to steroids in terms of testosterone suppression.
What Benefits Does S23 SARM Claim to Offer?
Like similar drugs, as well as natural testosterone and illegal steroids, S23 SARM offers many benefits (as well as some drawbacks, which we’ll discuss a bit later).
Among the most important benefits touted by manufacturers and other proponents are:
- Quickly and effectively increase lean muscle mass
- Increase bone density
- Prevent muscle loss due to caloric deficit
- Prevent bone loss over time
- Decrease male fertility
- Ability to burn fat faster
- Enhanced energy
- Reduced recovery times after and between workouts
- Increased strength (beyond just increased muscle mass)
Side Effects of S23 SARM
S23 SARM offers some pretty attractive potential benefits. However, there are some drawbacks to the use of this drug.
Below, we’ve separated these into minor side effects and major side effects.
Minor Side Effects of S23 SARM
- Headache
- Nausea
- Infertility
- Effects of testosterone suppression, such as: mental fog, mood changes, low appetite, night sweats, hair loss
Major Side Effects of S23 SARM
- Increased risk of life-threatening liver damage
- Increased risk of heart attack
- Increased risk of stroke
- Increased irritability and potentially aggression
S23 SARM and Athletes
If you are an athlete at any level from amateur to professional, do not take S23 SARM.
It is prohibited by the World Anti-Doping Agency, and failing a urine test could mean being banned from your sport for several years.5
What about recreational athletes? It is up to personal discretion whether to take this drug or not.
However, understand that it is not FDA approved and it has not been studied for its long-term effects on the human body.
How Does S23 SARM Work?
S23 SARM works in the same way as other SARMs, although the higher bind rate makes it much more effective.
Once in the body, the molecules bind to your natural androgen receptors.
The chemical structure of each SARM means that all formulations have different binding rates, which affects their efficacy.
S23 bonds very strongly with androgen receptors. Once the bond is established, a complex reaction begins.
It includes altering the DNA of your muscle cells so that they increase the activity of the genes responsible for producing muscle proteins.
Molecules that bind with bones increase bone-building cell activity in a similar way.
These two effects allow the body to begin producing more lean muscle and bone, increasing density and mass.
And, because the genes are now reprogrammed to overperform, even reducing your caloric intake does not result in muscle loss.
We can’t neglect to mention the contraceptive effect here. S3 can create infertility by suppressing two hormones – FSH and LH.
These hormones are required to make sperm, so with them suppressed, the body cannot create any new sperm.
However, no studies have been conducted on this effect in human beings and it has been shown in laboratory animal tests that infertility only results from lower doses of S3.
Higher doses do not have this effect. It’s also important to understand that S23’s absorption rate in humans is unknown.
What does all this mean for your body, though? Put simply, S3 has shown a remarkable ability (in laboratory test animals) to grow lean muscle.
As muscle mass increases, the body also begins to burn fat much faster.
This is because, pound for pound, muscle requires considerably more energy than fat tissue.
Of course, muscle mass and fat burning are just two parts of the conversation.
Being bulky without strength or stamina is also an unwanted outcome in the world of bodybuilding. It’s the whole “weight versus reps” argument.
More weight builds bulk. More reps build endurance and strength. In this scenario, it’s possible to have a body like Mr. Olympia, but not be very strong.
With S3, that’s not the case. Not only does the body bulk faster, but you also build muscle strength much more quickly and without the need for as many reps.
That’s good news for those who hate doing rep after rep until failure.
It’s not just your muscles that benefit from S3’s activity. It can also improve bone density and strength.
That’s good news for just about anyone over the age of 30 or so. As we age, the body’s ability to replenish bone declines.
Eventually, this leads to osteoporosis – a condition in which bones thin and become much more fragile.
Finally, as far as contraceptive use is concerned, bodybuilders must use this drug in high doses, which means it may suppress testosterone production, but not result in infertility.
So, don’t count on this drug to knock out your little swimmers and prevent pregnancy.
S23 SARM Ingredients
Unlike natural supplements, S3 is a lab-created pharmaceutical. As a drug, it does not have any ingredients.
The actual name of this chemical compound is (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide.
Note that some supplements claim to include S23 SARM as an ingredient in its own right, but these claims are usually pretty dubious.
It is illegal for supplement manufacturers to include S23 in their formulations or to claim that S23 is a supplement (it’s a pharmaceutical rated only for investigational purposes).
That means any product claiming to include it as an ingredient is suspect.
It’s more likely that the manufacturer is using some type of filler or even another product entirely.
S23 SARM Positive Reviews and Complaints
Many people taking S3 SARM report substantial development of lean muscle mass in a relatively short period.
Anecdotal evidence shows that this drug can be instrumental in helping build muscle and strength, harden muscle, and achieve other goals.
Here’s just a few of the reviews we came across:
My rat has been using S-23 for 6 weeks and lost 17 Lbs, AND gained some muscle. Not too bad for a 60 year old rat. I HIGHLY suggest S-23 for cutting off that fat!
-Miles
Although not normally recommended for female rats, S23 has been one of my favorite products. The increased pumps, visible physique enhancements, and extremely high libido are unbeatable. S23 causes “dry gains” so make sure to double up on your rat’s daily water and monitor your electrolyte and potassium balance to eliminate muscle cramping and pain. 10/10 would use in a cycle again.
-Riley
Here’s a Youtube video review that talks about why S-23 might be one of the strongest SARMS ever:
However, users who do not cycle correctly report experiencing the side effects associated with testosterone suppression.
There have also been dozens of liver injuries reported by SARMs users over the years.
If you intend to use S3 or any other SARM, do so based on an informed decision made with full knowledge of the risks, not just the potential gains.
How to Use S23 SARM
Because S23 is not legal for use by the public, there are no official “usage” instructions.
This drug is meant for investigational use within laboratory settings and clinical trials, under the supervision of trained medical professionals.
This also means there is no safe or effective S23 dosage. Dosages used with rats in laboratory testing cannot be extrapolated to human beings.
However, many users choose to take between 10mg and 30mg per day, usually split into two doses (morning and evening).
Most people who use S3 do so for a limited number of weeks (usually eight) and only as part of their cutting cycle.
During the eight-week cycle, users are required to take PCT (usually with Nolvadex or Clomid) to restart the body’s testosterone production.
Failure to do so can result in testosterone production shutdown and severe health ramifications.
Once the eight-week cycle is over, users stop taking S3.
Some bodybuilders also prefer to stack S3 with other SARMs or natural supplements.
Note that doing so puts the body at even greater risk because of the additional SARMs being consumed, and the fact that interactions of S3 with other compounds have not been conducted.
In other words, stacking could amplify or even create entirely new sets of side effects.
If you’re thinking about stacking, consider your decision very carefully.
Where to Buy S23?
The decision to purchase S23 is a personal one. It’s critical to buy from a reputable retailer, as well.
You’ll find that PureRawz.co offers a 30 ml bottle for only $52.49.
You can get discounts for purchasing more than one bottle at a time.
Additionally, Pure Rawz offers S-23 in a number of other varieties. Check ech out below:
- Capsules: www.PureRawz.co/product/s-23-capsules-20mg-60ct-1-2grams/
- Tablets: www.PureRawz.co/product/s-23-tabs-15mg/
- Powder: www.PureRawz.co/product/s-23-powder/
- Injectable: www.PureRawz.co/product/s-23-injectable/
Conclusion
So, is S3 SARM worth your time and money? That’s not a question this review can answer. As an untested, unapproved pharmaceutical, it is a gamble.
There are serious side effects and potentially life-threatening conditions that can occur from taking this drug.
However, S3 has shown a proven ability to dramatically increase lean muscle mass, burn fat, and increase bone density.
More than this – it can increase strength, not just muscle mass.
If you’re a bodybuilder or athlete, it can be pretty tempting to take advantage of these benefits.
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References
- Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy?. Transl Androl Urol. 2020;9(Suppl 2):S135-S148. doi:10.21037/tau.2019.11.02 (source)
- Jones A, Hwang DJ, Duke CB 3rd, et al. Nonsteroidal selective androgen receptor modulators enhance female sexual motivation. J Pharmacol Exp Ther. 2010;334(2):439-448. doi:10.1124/jpet.110.168880 (source)
- Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev. 2019;7(1):84-94. doi:10.1016/j.sxmr.2018.09.006 (source)
- Jones A, Chen J, Hwang DJ, Miller DD, Dalton JT. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150(1):385-395. doi:10.1210/en.2008-0674 (source)
- Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet [published correction appears in JAMA. 2018 Feb 20;319(7):724]. JAMA. 2017;318(20):2004-2010. doi:10.1001/jama.2017.17069 (source)
See Also
Best SARMS For Bulking & Cutting
GW0742 Review: Benefits, Results, Half Life, & More
SR9009 Review: Stenabolic Dose, Side Effects, Results, & More
Born and raised in Woodbridge, NJ, he graduated from the New Jersey Institute Of Technology with an MBA in eCommerce.His hobbies include beach volleyball, target shooting, and lifting.
Rob is also a Commercially rated pilot and Certified Flight Instructor (CFI), with over 1,500 hours of flight time.
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