sermorelin peptide review and results
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Sermorelin Review: 5 Big Benefits That Make It Worth Trying

Peptides are tiny chains of amino acids that are the building blocks of protein.

Sermorelin is a peptide naturally produced by the body to stimulate the release of growth hormones.

Growth hormone is essential for developing and maintaining muscle mass, bone density, and skin health. 

Our bodies produce less growth hormone, leading to muscle loss, weight gain, and other age related issues.

Supplementing with Sermorelin can help promote growth hormone release and slow aging.

Let’s learn more about how this peptide can help improve your overall health and well-being.

NOTE: The below peptides are NOT intended for those under the age of 18. If you are under the age of 18, do NOT consider taking them under any circumstances whatsoever.

What Is Sermorelin?

sermorelin peptide review and results

Note: Click Here to pick up Sermorelin from our #1 rated source, Core Peptides.

First created in the 1980s, Sermorelin is a man-made form of a hormone that helps to stimulate growth and production.1

This peptide hormone is similar to the naturally occurring growth hormone releasing hormone (GHRH).2

It works by binding to receptors in the brain responsible for releasing growth hormones.3

Sermorelin is typically used as part of a treatment plan for children suffering from a GH deficiency.4

It can also be used off label to help improve sleep, increase energy levels, and promote weight loss.5

It’s even been studied in the treatment of recurrent glioma, although more research is needed.6

Like many other growth hormone treatments, Sermorelin is administered via injection.7

Upon injection, it leads to an increase in cell reproduction and growth.

As a result, Sermorelin can help to improve muscle mass, bone density, skin elasticity, and organ function.

It can also help to reduce body fat and increase energy levels.

How Does Sermorelin Work?

As mentioned previously, Sermorelin works by regulating the production of growth hormones.

In doing so, Sermorelin can help the athlete recover from injury more quickly, build muscle mass, and improve metabolism.

In addition, growth hormone helps maintain muscle mass and bone density, and it also plays a role in metabolism.

Sermorelin also helps improve sleep quality, which is essential for optimal performance.

As a result, Sermorelin can be a valuable tool for athletes looking to improve their performance.

Sermorelin is often used in conjunction with other peptides, such as IGF-1, to maximize benefits.

Side Effects Of Sermorelin

Currently, Sermorelin is the only FDA-approved growth hormone releasing factor (GRF).

While there is no direct evidence that Sermorelin enhances athletic performance, there are some potential side effects that athletes should be aware of. 

These include increased thirst and urination, headaches, fatigue, joint and muscle pain, and flu-like symptoms.

In rare cases, Sermorelin can also cause high blood pressure and irregular heartbeat.

It is crucial to speak with a doctor before using a Sermorelin or any other performance-enhancing substance, as with any drug.

How To Use Sermorelin

With proper care and usage, Sermorelin can benefit men and women of all ages.

The best way to use Sermorelin will vary depending on the individual’s needs and medical situation. 

Intramuscular injections should be given slowly and carefully to avoid pain or tissue damage.

When using Sermorelin orally, it is vital to hold the dose under the tongue for at least one minute before swallowing.

This allows the supplement to be absorbed directly into the bloodstream for maximum effectiveness.

You should not use Sermorelin if you participate in NCAA or professional sports organizations in the US, as it has not been approved by WADA.8

Administration Tips of Sermorelin

Some general guidelines should be followed when taking Sermorelin.

The best time to take Sermorelin is 20-30 minutes before bedtime.

This will help ensure that the medication is absorbed correctly by the body. 

It’s also crucial to take Sermorelin on an empty stomach for the best results.

This means that you should not eat or drink anything for at least 30 minutes before taking the medication.

Keep in mind that it can take up to 3 months to achieve peak results, so don’t get discouraged if you’re not seeing instant results.

Lastly, be sure to store Sermorelin in a cool, dry place, away from direct sunlight, and out of reach from children and pets.

Stacking Sermorelin With Other Peptides 

There are a number of other peptides that work great in combination with Sermorelin.

These include Epitalon, Ipamorelin, GHRP-2, and GHRP-6, all of which have their own individual benefits.

Let’s take a brief look at each of these stacks to learn more about how they can help you accomplish your fitness objectives.

Sermorelin & Ipamorelin Stack

A popular peptide to stack with Sermorelin is Ipamorelin, as they share many of the same benefits and have complementary mechanisms of action.

In addition to promoting growth hormone production, Sermorelin and Ipamorelin can also help to improve sleep quality, increase energy levels, and reduce body fat.

As a result, if you’re looking for an effective way to improve your outcomes, Sermorelin, and Ipamorelin stacking may be the perfect solution.

Dosage Protocol and Duration

In order to get the best results, you should take Sermorelin and Ipamorelin as follows: 

  • Sermorelin: (0.25 – 1 mg) – 1 – 3 times a day
  • Ipamorelin: (0.25 – 1 mg) – 1 – 3 times a day

The dosage protocol and duration of stacking sermorelin and Ipamorelin can differ depending on a few factors.

Typically, the dosage will be between 0.5 and 1.0mg per day, and the stack duration will be anywhere from 4 to 8 weeks.

Sermorelin & GHRP-6 Stack

Another popular peptide to stack with Sermorelin is GHRP-6, which is another growth hormone releasing peptide (GHRP).

The benefits of stacking Sermorelin & GHRP-6 Stack include:

  • Enhanced release of growth hormone
  • Increased fat metabolism
  • Increased muscle mass
  • Improved joint health
  • Increased bone density

Together, these two compounds provide a full growth hormone release than either compound alone.

Dosage Protocol and Duration

When stacking Sermorelin & GHRP-6, the recommended dosage is 100mcg of each peptide stacked together once per day.

This dosage can be increased to twice per day if desired, but it is not necessary to exceed 100mcg per day.

The average dosage protocol for a person wanting to build muscle and lose fat would be 3-5IU of GH per day, split into two even doses, taken with food. 

The duration of the stack will depend on the goals of the individual. Still, it is typically recommended to cycle off after 8-12 weeks of use.

This will help prevent unwanted side effects and allow your body to recover.

Sermorelin & GHRP-2 Stack

The benefits of stacking Sermorelin & GHRP-2 Stack are numerous. It can help to:

  • Increase muscle growth
  • Reduce unwanted fat
  • Repair damaged tissue
  • Improve sleep quality
  • Reduce anxiety
  • Increase energy

If you are looking for a way to feel your best, stacking Sermorelin & GHRP-2 may be the answer.

Dosage Protocol and Duration

The dosage protocol and duration when stacking Sermorelin & GHRP-2 is to start with a low dose and increase gradually over time as needed and as tolerated.

The usual starting dose is 1-2 mcg per injection, given 2-3 times per day. 

This can be increased by increments of 1 mcg every 4-7 days as needed and tolerated up to a maximum of 5 mcg per injection.

The total daily dosage should not exceed 10 mcg. Once the desired dosage is reached, it should be continued for 3-6 months before re-evaluate.

Sermorelin & GHRP2 & GHRP6

Yet another popular stack with Sermorelin is to combine it with both GHRP-2 and GHRP-6.

As we mentioned earlier, Sermorelin, GHRP2, and GHRP6 are peptides that have all been shown to promote growth hormone release.

Some of the benefits of stacking Sermorelin & GHRP2 & GHRP6 include increased lean body mass, improved fat loss, and reduced recovery time from exercise.

Additionally, this stack can help enhance sleep quality and increase energy levels. 

Stacking Sermorelin & GHRP2 & GHRP6 has actually been shown to cause less side effects than using any of the drugs individually. 

Dosage Protocol and Duration

When taking the 3 combined, the recommended dosage protocol and administration of Sermorelin & GHRP2 & GHRP6 is as follows:

  • Sermorelin: 0.3 mg per kilogram of body weight injected subcutaneously once a day
  • GHRP-2: 1-2 mcg/kg injected subcutaneously 2-3 times a day
  • GHRP-6: 50-100 mcg/day injected subcutaneously 2-3 times a day

These dosages may need to be adjusted based on individual responses.

Sermorelin Reviews / Testimonials

We went through a ton of websites, including sites like Reddit and Quora, to try and get a sense of what people who’ve take Sermorelin had to say.

The vast majority of them agreed that Sermorelin is most effective when stacked with another peptide, such as CJC 1295 or Ipamorelin.

Check out a few of the more informative reviews below: 

“I have been on 300 mcg every evening of Sermorelin now for exactly 6 months and have started to realize the benefits as of the last few weeks, (improved sleep, increased muscle, healing, fat loss).”
– Reddit User

“I’m taking it now…it gives me better sleep. They also put me on test and hcg. The total was higher than expected for a 2-3 month supply. The iPad/serm was the most expensive -$450 just for that 5x/week.”
– ECore / Reddit

“I feel stronger and better with it. Sleep better and perform better in the gym”
– TooMuchBasalGanglia / Reddit

‘Anabolic Cartel’ did a Youtube video a couple years back, and provided a great review its benefits, and before and after results from users : 

Where To Buy Sermorelin

We highly recommend that you pick up Sermorelin from a company called Core Peptides.

Not only do they sell the highest quality peptides on the internet, but they do so at very reasonable prices.

Click Here to see their page on Sermorelin.


If you’re looking for a way to boost your results from Sermorelin therapy, consider stacking it with peptides. 

Ipamorelin and GHRP-6 are both popular choices that can help to amplify the effects of Sermorelin. 

Ipamorelin is a Growth Hormone Releasing Peptide (GHRP) that helps to stimulate growth hormone release. 

At the same time, GHRP-6 is a Ghrelin mimetic that helps to increase appetite.

Stacking these two peptides with Sermorelin can help to produce even better results, including increased muscle mass, improved fat loss, and enhanced recovery from injuries.

It’s important to remember that you’ll need to be careful about dosage when stacking Sermorelin with peptides.

Too high of a dose can lead to unwanted side effects like headaches and nausea. 

There’s no one-size-fits-all answer for peptide stacking, so it’s essential to experiment and find what works best for you.

In general, it’s best to start with a lower amount and increase gradually as needed.

You should also watch your progress and how your body responds to the different peptides. Suppose you’re not seeing the results you want.

In that case, it may be necessary to adjust your doses or try a different combination of peptides.


  1. Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?. Clin Interv Aging. 2006;1(4):307-308. doi:10.2147/ciia.2006.1.4.307 (source)
  2. Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?. Clin Interv Aging. 2006;1(4):307-308. doi:10.2147/ciia.2006.1.4.307 (source)
  3. National Center for Biotechnology Information. PubChem Compound Summary for CID 16129620, Sermorelin. Accessed June 5, 2022. (source)
  4. Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999;12(2):139-157. doi:10.2165/00063030-199912020-00007 (source)
  5. Sinha DK, Balasubramanian A, Tatem AJ, et al. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020;9(Suppl 2):S149-S159. doi:10.21037/tau.2019.11.30 (source)
  6. Chang Y, Huang R, Zhai Y, et al. A potentially effective drug for patients with recurrent glioma: sermorelin. Ann Transl Med. 2021;9(5):406. doi:10.21037/atm-20-6561 (source)
  7. Khorram O, Laughlin GA, Yen SS. Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. J Clin Endocrinol Metab. 1997;82(5):1472-1479. doi:10.1210/jcem.82.5.3943 (source)
  8. Memdouh S, Gavrilović I, Ng K, Cowan D, Abbate V. Advances in the detection of growth hormone releasing hormone synthetic analogs. Drug Test Anal. 2021;13(11-12):1871-1887. doi:10.1002/dta.3183 (source)

See Also 

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4.7 out of 5 (55 Ratings)

Sermorelin is a peptide that claims to produce numerous benefits, but does it really work? Find out more in our comprehensive review.
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