tb 500 peptide review and results
Recommended Products

TB-500 Peptide: Benefits, Dose, Side Effects, & More

There are days when it’s effortless to get out of bed and there are days when it’s the complete opposite.

Perhaps your body aches or you constantly feel tired and depleted?

For many, getting older is no fun.

However, that doesn’t mean you have to settle for a lackluster lifestyle.

Peptides like TB-500 are making a lot of noise in the world of fitness and weight lifting.

TB-500 is known to repair muscle as well as stimulate growth leading to some significant improvements in overall health.

Learn more about TB-500 Peptide in our complete review.

IMPORTANT: The below peptides are NOT intended for those under the age of 18. If you are under the age of 18, do NOT consider taking them under any circumstances whatsoever.

What Is TB-500?

tb 500 peptide review and results

Click Here to pick up TB-500 from our #1 rated source, Core Peptides.

TB-500 is a synthetic peptide that replicates a naturally occurring healing protein known as Thymosin Beta 4 (TB4).

Thymosin Beta 4 is present in all humans and mammals.

Research indicates that TB-500 may treat a variety of autoimmune diseases, infections, and traumatic brain injuries.

Furthermore, the peptide is linked to muscular function as it repairs tissue while also stimulating new growth.1

Studies have also connected TB-500 to a potential treatment for controlling muscle spasms.

For this reason, TB-500 is becoming more noteworthy in the fitness industry as a safer alternative to performance-enhancing drugs like anabolic steroids.

TB-500 offers several benefits including the ability to heal wounds and injuries, contributing to faster recovery times.

Moreover, the peptide is efficient at improving flexibility while also reducing inflammation.

TB-500 is able to produce all of these benefits by influencing blood cell and blood vessel development as well as cellular migration.

The peptide is capable of providing healing properties thanks to its regulation of actin.2

Actin serves as a cell-building protein that is central to repairing wounds and other types of healing.3

Unfortunately, the U.S. government has been slow to study the impacts of peptides like TB-500 and therefore remains outside the regulation of the FDA.

While that does not designate TB-500 as unsafe for consumption, users should be aware of the lack of government oversight.

It makes the substance ripe for being taken advantage of by illegitimate suppliers seeking to cash in on artificial products.

Benefits of TB-500

TB-500 is designed to replicate the effects of Thymosin Beta 4 (TB4).

As a result, it features several noteworthy benefits including the ability to heal wounds, reduce inflammation, and improve flexibility.

All of these qualities make TB-500 an ideal substance for improving recovery time between workouts.

Thus, you’ll spend less time on the sidelines recovering and more time redefining the body.

More importantly, TB-500 displays the ability to influence muscle growth as well as repair damaged tissue.

The top benefits of using TB-500 as a supplement include:

  • Regenerates blood cells
  • Muscle growth and repair
  • Reduces inflammation in joints and muscles
  • Improves recovery time
  • Heals wounds and damaged tissue scarring
  • Reduces pain and aches
  • Improves overall endurance and stamina

TB-500 is effective by focusing on cellular activity.

Consequently, the peptide primarily focuses on influencing natural processes such as:

  • Cell and Blood Vessel Development
  • Cellular Differentiation
  • Angiogenesis (Growth of New Blood Cells)
  • Cellular Migration 

TB-500 is also linked to Keratinocyte Migration and Collagen Deposition.

Lastly, it has been demonstrated to relax muscle spasms while improving overall muscle tone.

How Does TB-500 Work?

TB-500 is effective at treating a variety of conditions as a synthetic alternative to Thymosin Beta-4.

The peptide is part of a family of 16 related molecules that feature high conservation of sequence and localization in most tissues and cells.

TB-500 binds to actin – a naturally occurring healing protein in the body of all humans.

It helps stimulate muscle growth while repairing damaged tissue.

The ability to influence actin is significant considering that out of the thousands of proteins in the human body – it represents nearly 10% of the total proteins.

Thus, it’s impossible not to recognize its influence over dictating the genetic makeup of the cell.

Further, TB-500 is known to block actin polymerization and sequester the molecule in eukaryotic cells.

The peptide has been identified as a noteworthy gene during early blood vessel formation and is therefore connected to muscular growth.

It’s also present in the fluid of wounds as a naturally-occurring healing aid that accelerates recovery time from injury.4

What’s more, the essential peptide promotes cell migration through a specific interaction with actin in the cellular cytoskeleton.

TB-500 is different from other peptides in that it promotes endothelial and keratinocyte migration, too.

You can learn more about the positive effects of TB-500 by studying what it attempts to replicate – Thymosin Beta-4 (TB4).

Initial research is promising and has prompted multiple clinical studies across the globe for repairing wounds in the tissue, skin, cornea, and heart.

However – like most peptides – it continues to remain outside regulatory efforts because of the lack of FDA approval.

Side Effects of TB-500

We’ve already covered all the reported benefits of TB-500, but what about side effects?

Customers must rely on user testimonials and reviews since the peptide is not regulated by the FDA.

With that being said, there do not appear to be any serious side effects related to TB-500 use.

In general, the substance is well tolerated and humans as well as deemed far safer compared to performance-enhancing drugs.

Peptides do carry some traditional side effects such as nausea or lightheadedness.

Also, flu-like symptoms are sometimes present with new users.

Nevertheless, these side effects are not present in every user and generally categorized as mild to moderate.

Thus, symptoms may disappear simply by lowering the dosage.

Regardless, it never hurts to speak with a physician before starting TB-500.

It’s especially important if you suffer from a preexisting condition or take other prescription meds.

How To Use TB-500

TB-500 is typically available in a powder or liquid substance.

Therefore, users have the option of injecting the peptide or mixing it into a supplement for daily consumption.

While TB-500 is technically only available for “research purposes” there is advice as to what represents a correct/set dosage.

For example, some sources suggest starting with a dosage between 5-20mg per week.

Meanwhile, clinical studies have utilized far lower doses (2-5mg p/ week), administrated twice weekly, for 4-8 weeks.

Starting with a low dose allows you to monitor changes in the body including any unwanted side effects.

TB-500 is not intended to take daily as most inject the peptide 2-3x per week.

Then, once the peptide is built up in the system, it’s wise to reduce the dosage to about half of the original injection.

Those that purchase TB 500 for consumption should store the product at room temperate in a non-humid environment.

It’s important to protect the peptide from direct sunlight.

Does TB-500 Work?

There is growing support for the use of TB-500 and other peptides to influence muscle growth and repair tissue.

However, much of this reputation is shared through personal anecdotes since the substance is not FDA-approved.

Unfortunately, the lack of acknowledgment has also contributed to limited studies on the subject.

Nevertheless, TB-500 is endorsed by several experts in the fitness and bodybuilding industries.

The unique molecular structure of TB-500 enables the peptide to cover long distances in the body.

That, and its known ability to influence actin in the body, makes it a prime solution for treating wounds and other injuries.

Users also report noticing reduced inflammation as well as improved flexibility.

TB-500 is capable of repairing the body thanks to its ability to steer blood cell and blood vessel development, cell migration, and cellular differentiation.

You can learn more about the positive effects of TB-500 by studying what it attempts to replicate – Thymosin Beta-4 (TB4).5

There are far more clinical studies on the naturally occurring protein compared to the synthetic version, most of which offer promise as a remedy.

In the past, clinical trials of TB4 have been conducted to monitor its effects on the tissue, skin, kidneys, cornea, heart, and tumors.6 7 8

The thymus gland produces TB4 and its generally found in high concentrations in wound fluids.

Thus, it has been studied to facilitate the healing and recovery of tissue in the body.

In animals, Thymosin Beta-4 has proved to improve blood vessel growth, decrease inflammation, accelerate recovery time, and reduce damage to the heart and central nervous system.

It’s what has led to TB-500 being monitored as a synthetic alternative for muscle growth and repair.

How Long Does It Take to See Results from TB-500?

There are varying accounts on how long it takes to witness results from TB-500, just like the set dosage.

For example, a 2-4 week cycle at a higher dose will affect the body differently from a lower dose, 4-8 week cycle.

Despite the lack of clarity, some users report noticing changes almost immediately – within days!

However, a more reasonable time-frame is 4 weeks for most users.

The weekly dosage, method of intake, and quality of the peptide may influence results.

The unique molecular structure of TB-500 allows the synthetic peptide to travel long distances in the body.

Consequently, impressive results are plausible with TB-500 supplementation so long as you stick to a safe and reliable manufacturer.

How to Get the Best Results from TB-500?

It’s natural to have reservations about any substance not approved by the FDA.

Be that as it may, there are many indications to suggest TB-500 is safe for consumption at low doses.

It has produced zero to minimal side effects in animals and human studies.

Even more, the peptide has demonstrated an ability to help individuals recover faster from wounds and injuries.

There are many that consider TB-500 vital to protecting and regenerating the body despite limited research.

Still, we only recommend purchasing from a reliable manufacturer that third-party tests its peptides and produces a Certificate of Analysis.

There are many artificial or unsafe products on the market which makes shopping from a dependable supplier all the more important.

Secondly, avoid overdosing by sticking to the lowest possible dose that displays results.

Overdosing can lead to unwanted side effects and may do more harm than good.

Third, make sure you properly store the substance and consider what method of intake (injection, powder, etc.) is appropriate for your needs.

Lastly, consider speaking with a physician before starting any peptide, including TB-500.

Stack TB-500 With Other Peptides

TB-500 remains an experimental substance that is intended for “research purposes”.

Accordingly, experimenting with TB-500 is necessary to find the proper dosing schedule.

There are many in the fitness world that build a weight stack to lose weight or gain lean muscle.

Thus, it’s possible to stack TB-500 with other peptides or SARMs to achieve a complete body overhaul.

The peptide BPC 157 is one of the more prevalent to stack with TB-500.

The 2 peptides function together to expedite healing and recovery time.

BPC 157 focuses more on healing soft tissue injuries such as tendons and ligaments.

Meanwhile, others prefer stacking TB-500 with CJC 1295, Ipamorelin, or Sermorelin (GHRH).

There are extra precautions to consider when stacking multiple peptides together.

Therefore, discontinue use immediately if severe side effects appear.

Where To Buy TB-500

While there are dozens of peptides sources online, we highly recommend you pick up TB-500 from our #1 rated choice, Core Peptides.

Click Here to see their page on TB-500.


There is so much to get excited about TB-500.

The potent, synthetic alternative to Thymosin Beta 4 (TB4) can revitalize your body.

TB-500 Peptide is known to accelerate recovery time by healing wounds and injuries faster.

Moreover, TB-500 has the potential to repair muscle tissue as well as stimulate new growth.

It’s worth considering if you suffer from a serious injury, deal with body aches and pain, and suffer from poor flexibility.


  1. Maar K, Hetenyi R, Maar S, et al. Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies. Cells. 2021;10(6):1343. Published 2021 May 28. doi:10.3390/cells10061343 (source)
  2. Dominguez R, Holmes KC. Actin structure and function. Annu Rev Biophys. 2011;40:169-186. doi:10.1146/annurev-biophys-042910-155359 (source)
  3. Ho EN, Kwok WH, Lau MY, et al. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012;1265:57-69. doi:10.1016/j.chroma.2012.09.043 (source)
  4. Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL. The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients. Ann N Y Acad Sci. 2012;1270:37-44. doi:10.1111/j.1749-6632.2012.06717.x (source)
  5. Su L, Kong X, Loo S, et al. Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells. Stem Cell Res Ther. 2022;13(1):13. Published 2022 Jan 10. doi:10.1186/s13287-021-02687-x (source)
  6. Vasilopoulou E, Winyard PJ, Riley PR, Long DA. The role of thymosin-β4 in kidney disease. Expert Opin Biol Ther. 2015;15 Suppl 1:S187-S190. doi:10.1517/14712598.2015.1009891 (source)
  7. Sosne G, Qiu P, Kurpakus-Wheater M. Thymosin beta 4: A novel corneal wound healing and anti-inflammatory agent. Clin Ophthalmol. 2007;1(3):201-207. (source)
  8. Moon EY, Song JH, Yang KH. Actin-sequestering protein, thymosin-beta-4 (TB4), inhibits caspase-3 activation in paclitaxel-induced tumor cell death. Oncol Res. 2007;16(11):507-516. doi:10.3727/096504007783438349 (source)

See Also 

Best Peptide Sources / Companies

Best Peptides For Muscle Growth

Rob V.
TB-500 Peptide

TB-500 Peptide

4.7 out of 5 (45 Ratings)

TB-500 is a synthetic version of a naturally occurring protein in the body crucial to healing injuries. Learn more about the potent peptide.
Affiliate Disclosure: This post may contain affiliate links. If you click and purchase, I may receive a small commission at no extra cost to you. I only recommend products I have personally vetted. Learn more.

Leave a Reply

Your email address will not be published. Required fields are marked *