thymosin beta 4 peptide review and results
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Thymosin Beta 4 (TB4) Peptide: Benefits, Dosage, Side Effects, & More

Have you noticed that it is taking longer for your wounds to heal and your injuries to fully recover?

This happens to a lot of people, particularly as they start to get older.

Most people start to worry about their health and well-being when they see that their body is no longer quite as capable of healing as it used to be.

They look for means to help turn back the hands of time.

Fortunately, certain things can be done that will help with these types of health issues.

One option to consider is to take TB-500, which is the synthetic replica of Thymosin Beta 4.

It could be just the thing you need to renew your body’s recovery system.

Let’s get a closer look at what this is and why it could be something you want to add to your routine.

IMPORTANT: The below peptides are NOT intended for those under the age of 18. If you are under the age of 18, do NOT consider taking them under any circumstances whatsoever.

What Is Thymosin Beta 4?

thymosin beta 4 peptide review and results

Note: Click Here to pick up Thymosin Beta 4 from our #1 rated source, Core Peptides.

Thymosin Beta 4 is a natural compound that was first identified in 1981.1

Thymosin Beta 4 is a peptide. It features a chain of 42 amino acids and is also known by the name timbetasin.2

It was isolated from a bovine thymus gland sample.

The synthetic version, TB-500, was developed in the early part of the 2010s and was initially believed to be helpful for veterinary purposes including horse racing.3

However, it was banned from competitive horse racing, one of its initial purposes, as well as other sports competitions.

However, research into the compound continues, particularly with TB-500.

The peptide has started to create quite a bit of interest in those who are looking into how its properties could help humans.

There have been a few human trials already, and it has shown a lot of promise for helping to promote joint and tissue strength, endothelial health, muscle repair, and wound healing.4

Other researchers have been looking into how it may be able to help with other health applications including anti-aging, inflammation, and cardiovascular health.

The synthetic version of Thymosin Beta 4 is available and could be a good option for those who are looking to learn more about these types of benefits.

Below, we will be getting a closer look at how it works in the body.

How Does Thymosin Beta 4 Work?

Thymosin Beta 4 and TB-500 work to help the body recover faster by increasing the amount of actin in the body.

It can help to boost the positive effects that actin has on the body.

Actin, of course, is responsible for helping with cell migration and proliferation.

It plays a role in new cell structure and can help them to move faster and determine their form.

New blood vessels form, and it can help with the regulation of inflammation. Those actions help to optimize healing and recovery.5

You will also find that the TB-500 can travel long distances within the body due to its molecular structure.

This means that it can be used to help local sites of injury where it is injected, as well as injury sites that are further away.

It can help to reduce inflammation and improve flexibility.

Benefits of Thymosin Beta 4

Why should you consider getting TB-500? Let’s look at some of the benefits that can come from using this peptide.

While a lot of the research has been done with animals or in test tubes, the results show a lot of promise with human applications to help with muscle and connective tissue growth, as well as cardiovascular function.

A lot of the research has been done on Thymosin Beta 4, which is the natural version of the synthetic TB-500.

However, because TB-500 is identical, albeit synthetic, the results are the same.

Muscular Benefits

Research has started to show that there are some fantastic muscle benefits when it comes to TB-500 for both skeletal muscle and cardiac muscle.6

A study on mice found that the use of Thymosin Beta 4 improved the skeletal muscle fiber regeneration who were lacking a connective tissue protein known as dystrophin.

There is some evidence showing that it could help to provide some protection to the cardiac muscle and could help to repair the heart.

Connective Tissue Benefits

Some research has shown that there are benefits when it comes to helping with the connective tissues, as well.

The joints, tendons, and even collagen matrices could benefit from the use of TB-500.7

An animal study conducted on rats with incision wounds found that those who were treated with Thymosin Beta 4 healed with minimal scarring compared with those in the control group.8

This was because the Thymosin Beta 4 helped to create tighter, more organized collagen fibers to help the body heal.

So not only will it help with wound healing, but it can also reduce the appearance of scars from certain types of wounds.

Healing of Skin Injuries and Other Benefits

There were human trials that studied venous ulcers on the skin.

The research found that the rate of healing was faster in those who were taking the Thymosin Beta 4.

Additionally, it has been found to be helpful when it comes to the health, development, and growth of blood vessels.

Users also appreciate the reduced inflammation not just at the site of the injection, but throughout the body.

People report having improved flexibility, along with better and faster overall recovery.

It truly does have a lot of benefits and may well be worth considering.

Side Effects of Thymosin Beta 4

Of course, before you consider taking any sort of supplement, whether it’s natural or synthetic, you need to know the side effects.

Thus far, the research on TB-500 has shown there to be minimal to no side effects when used in proper doses.

A safety study was done in 2010 and found that it was well-tolerated and presented a minimal risk.

Because it is a peptide, though, some might feel nauseous or lightheaded when injecting it. Others may have headaches.

This tends to be rare, though, and most people should not have any issues.

Does Thymosin Beta 4 Really Work?

One of the other questions that most people are going to ask of themselves before taking something like Thymosin Beta 4 and TB-500 is whether it truly works or not.

After all, they don’t want to spend a lot of money on a product that won’t produce results.

Fortunately, this product truly does work and can provide benefits like those mentioned above.

Many people have had positive results with the product, and you can do the same.

How to Use Thymosin Beta 4

When buying the freeze-dried powder, you will need to first reconstitute it using bacteriostatic sodium chloride 0.9%.

The most common dosages of the reconstituted TB-500 are going to be between 2 mg and 5 mg.

It should be administered two times per week for between four and eight weeks.

Some prefer starting with a higher dose for the first one to two weeks, and then they will drop it down by half for the remaining weeks.

Where To Buy Thymosin Beta 4

We recommend that you pick up Thymosin Beta 4 from our #1 recommended source, Core Peptides.

Click Here to see their page on Thymosin Beta 4.


The older you start to get, the harder it becomes to recover from all of the injuries you might face.

Even dealing with workout recovery becomes more difficult and takes a lot longer. Your muscles and joints hurt and aren’t what they used to be.

However, with Thymosin Beta 4, this doesn’t have to mean the end.

As you have seen from the information above, this could be just what you need to get over your injuries.

If you are struggling with recovering from workouts, injuries, wounds, etc., consider taking TB-500.

It has a lot of benefits, and it could help to get you and your body back on the right track physically.

This is a viable option that really works.


  1. Erickson-Viitanen S, Ruggieri S, Natalini P, Horecker BL. Distribution of thymosin beta 4 in vertebrate classes. Arch Biochem Biophys. 1983;221(2):570-576. doi:10.1016/0003-9861(83)90177-7 (source)
  2. National Center for Biotechnology Information. PubChem Compound Summary for CID 16132341, Thymosin beta4. Accessed June 4, 2022. (source)
  3. Ho EN, Kwok WH, Lau MY, et al. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012;1265:57-69. doi:10.1016/j.chroma.2012.09.043 (source)
  4. Goldstein AL, Kleinman HK. Advances in the basic and clinical applications of thymosin β4. Expert Opin Biol Ther. 2015;15 Suppl 1:S139-S145. doi:10.1517/14712598.2015.1011617 (source)
  5. Xu TJ, Wang Q, Ma XW, et al. A novel dimeric thymosin beta 4 with enhanced activities accelerates the rate of wound healing. Drug Des Devel Ther. 2013;7:1075-1088. Published 2013 Oct 1. doi:10.2147/DDDT.S50183 (source)
  6. Banerjee I, Zhang J, Moore-Morris T, et al. Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012;110(3):456-464. doi:10.1161/CIRCRESAHA.111.258616 (source)
  7. Philp D, Badamchian M, Scheremeta B, Nguyen M, Goldstein AL, Kleinman HK. Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice. Wound Repair Regen. 2003;11(1):19-24. doi:10.1046/j.1524-475x.2003.11105.x (source)
  8. Malinda KM, Sidhu GS, Mani H, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-368. doi:10.1046/j.1523-1747.1999.00708.x (source)

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