igf-1 lr3 peptide benefits
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IGF 1 LR3 Peptide Review: Benefits, Dosage, Results, & More

IGF 1 LR3 may sound like a hidden code and, in a sense, does represent a secret not many are aware exists.

It’s short for Insulin-like Growth Factor LR3 which is considered a more potent variant of IGF-1.

There are many fitness experts that rely on Human Growth Hormone (HGH) when it comes to bulking up and gaining muscle mass.

As a result, IGF 1 LR3 promotes lean muscle and contributes to a stronger, healthier body.

Learn more about IGF 1 LR3 peptide in our complete review.

IMPORTANT: The below peptides are NOT intended for those under the age of 18. If you are under the age of 18, do NOT consider taking them under any circumstances whatsoever.

What is IGF 1 LR3?

igf-1 lr3 peptide benefits

Note: Click Here to pick up IGF 1 LR3 from our #1 rated source, Core Peptides.

IGF 1 LR3 is a polypeptide, or protein hormone, that features an intriguing chemical structure.1

The peptide displays a chemical structure similar to the natural insulin hormone produced in the pancreas and liver.2

Consequently, the synthetic version has the potential to influence a number of critical functions of the body.3

First, IGF 1 LR3 targets the endocrine hormone Insulin-like Growth Factor (IGF-1) in the liver.4

Secondly, the stimulation of IGF-1 contributes to the release of Human Growth Hormone (HGH).5

HGH is essential to many functions of the body including stimulating muscle growth.

For example, IGF-1 is generally most prevalent during puberty where it contributes to a growing body and the development of lean muscle.

However, as individuals age (both male and female) the body generally releases less IGF-1 and, therefore, HGH.

The discovery has led researchers to examine the various ways IGF 1 LR3 may benefit the human body.

For starters, researchers already know that IGF 1 is terrific at promoting muscle growth.6

Even better, studies indicate that IGF 1 LR3 is more potent and effective at building lean muscle compared to the standard form.7

It has prompted manufacturers to develop synthetic forms of the hormone.

And, unlike many peptides and hormonal injections, the U.S. Food and Drug Administration (FDA) has approved recombinant IGF-1 for use.

Currently, the peptide is connected to improving:

  • Muscle Mass
  • Protein Synthesis
  • Cellular Production & Health
  • Glucose Transport
  • RNA Synthesis

Nevertheless, there is still much to learn about IGF 1 LR3 as clinical studies remain pending on the long-form version of the peptide.

Still, the NIH confirms that the substance does not demonstrate the same damaging properties as anabolic steroids for developing lean muscle.8

How Does IGF 1 LR3 Work?

IGF 1 LR3 is a polypeptide that influences insulin response, regulates DNA synthesis, and stimulates muscle growth.

The peptide features an impressive ability to not only influence tissue, but bone, cartilage, nerves, and organs, too.

Amino acids are essential building blocks of all proteins that are utilized in the body.9

The long-version of Insulin-like Growth Factor 1 is classified as a “Human Recombinant”.

Recombinant proteins are encoded with DNA enclosed in an expression vector.

These types of proteins get manipulated from the native version yet still assist with the same critical functions of the body.

As a result, polypeptides like IGF 1 LR3 are capable of stimulating natural processes such as modifying gene sequences.

For this reason,  the peptide is purposely designed to improve biological activity like promoting muscle growth.

The chemical structure of the long-version of IGF-1 is slightly altered to serve as an agonist for the receptor.

Consequently, the long-form version features a low affinity for the insulin-like growth factor-binding proteins (IGFBPs).

Furthermore, IGF 1 LR3 offers improved metabolic stability which contributes to the peptide being 3x more potent than regular IGF-1.10

Lastly, the long-form version possesses a significantly longer half-life (20-30 hours).11

Benefits of IGF 1 LR3

IGF 1 LR3 is one of the most popular peptides available, especially for gaining lean muscle.

The peptide is notorious for producing significant results in terms of muscle growth and muscle mass.

The compound targets insulin which is the most powerful growth hormone in the body.

For this reason, it’s little surprise that bodybuilders witness impressive muscle growth results.

Meanwhile, those that are seeking more than just an overhaul of the body can appreciate the following benefits of IGF 1 LR3:

  • Builds Lean Muscle
  • Improves Muscle Mass
  • Burns Excess Fat
  • Boosts Metabolic Rate
  • Reverses Insulin Sensitivity
  • Improves Sleep & Energy
  • Improves Libido

There is some evidence to suggest that the peptide benefits cognitive function and mental well-being.

In the past, physicians have prescribed the hormone for youth struggling with developmental issues.

Moreover, IGF-1 therapy is often necessary for patients with muscle-wasting effects from devastating diseases such as HIV/AIDS.

IGF 1 LR3 peptide is also effective at burning excess fat and transforming it into an energy source.

As a result, the peptide is effective at weight loss and improves overall metabolism in the process.

The peptide assists those recovering from injury (particularly tissue and nerve damage injuries).

Finally, IGF 1 LR3 helps individuals gain weight yet without water retention (like with anabolic steroids).

In fact, the same serious/dangerous side effects of steroids are not witnessed with bodybuilders.

Side Effects of IGF 1 LR3

What’s amazing about IGF 1 LR3 is that the synthetic peptide is very potent yet not known to produce dangerous side effects.

However, with that being said, it’s not to acknowledge that there is a risk of abusing it (which does lead to adverse side effects).

Thus, the safest and most effective way to handle IGF 1 LR3 is to follow the proper cycle and dosage instructions (more information, below).

Those that experience symptoms from IGF-1 supplements generally cycle for too long or consume high doses.

The long-form version is very effective at promoting lean muscle and muscle mass development when used correctly.

The most common side effects of IGF 1 LR3 include:

  • Nausea
  • Headaches
  • Low Blood Sugar

These side effects are generally mild and do not linger long-term with the proper cycle.

However, if symptoms continue to persist you should discontinue use immediately.

Lastly, there are some users that report “bubble gut” from using IGF 1 LR3.

There is still more research necessary to determine if the peptide is the direct cause of the condition which causes bloating in the organs.

We suggest speaking with a licensed physician before use if you have any questions, concerns, or doubts about the substance.

There are certain medical conditions or prescription medications that may interfere or cause reactions.

Does IGF 1 LR3 Work?

The reputation in the gym and clinical studies is stellar aside from a few concerns.

However, in the future, more research will help affirm what medical experts already know about the powerful peptide as well as erode any doubts.

Until then, IGF 1 LR3 peptide remains largely experimental despite all the endorsements at the gym.

There are several variants of Insulin-like Growth Factor (IGF) each with its own potential as well as limitations.

Regardless, the peptide is effective at stimulating muscle growth for developing lean muscle and mass.

In general, IGF-1 is primarily utilized to start natural processes that influence the production of Human Growth Hormone (HGH).

It’s vital to remind users that IGF-1 and its long-form version do not produce the same effect as HGH.

Therefore, many combine IGF 1 LR3 with HGH into a weight stack designed for gaining lean muscle.

Whereas IGF-1 has a direct muscle-building impact, HGH stimulates receptors that are responsible for producing IGF-1.

Consequently, HGH serves as a precursor hormone to the creation of IGF-1.

Insulin-like Growth Factor (IGF) has a very short half-life (often less than 10 minutes) which is why the long-form version was engineered.

All in all, the two hormones help each other out in the body while ultimately benefiting you the most.

How to Use

IGF 1 LR3 is extraordinarily powerful.

In fact, studies report the recombinant protein is over 3x more potent than the standard form (IGF).

For this reason, we suggest keeping in mind the potency of the long-form version.

The peptide is extremely effective at building mass but you need to cycle it properly to avoid unwanted effects.

First, start with a low dose and monitor side effects (if any) observing how the substance interacts with your system.

You’ll get varying accounts as to the “correct” dosage for IGF 1 LR3.

In general, the norm is to begin anywhere from 20-50mcg per day.

Then, users may want to consider bumping the dose up higher to achieve better results.

Thus, it’s not uncommon to hear of those in the gym supplementing between 50-80mcg per day.

IGF 1 LR3 Cycle Instructions

These injections usually occur for a cycle that spans between 4-6 weeks.

It’s very important not to over exceed the cycle to avoid unwanted, permanent effects.

For example, “bubble gut” is an uncommon side effect yet generally occurs as a result of taking for longer than 1-2 months.

There are many that suggest starting with an introductory cycle of IGF 1 LR3 that does not exceed 30 days.

While there are no set guidelines for use it never hurts to start “low and slow” with new supplements.

You may want to bulk as much muscle as possible (and IGF 1 LR3 can certainly get you there) but exercise caution.

The hormone is very potent so utilize good references in terms of proper usage.

Furthermore, remain mindful that the substance is not designed to be taken more than once per day (because of the long half-life).

In terms of the time of day to consume, most recommend just prior to workout (10-30 minutes) to maximize results.

Additionally, it never hurts to speak with a physician before introducing any new supplement to the body.

Lastly, make sure you only purchase from a trustworthy source for peptides and SARMs.

We recommend Core Peptides given their long track record and high-performance standards.

Click Here to see their page on IGF1 LR3.

How to Get the Best Results

There is nothing like insulin in terms of generating muscle thanks to the production of the Human Growth Hormone (HGH).

Unfortunately, the short half-life of standard/natural form IGF makes it unreliable for supplementing muscle growth.

However, its synthetic alternative is capable of stimulating the same natural processes yet is 3x more potent and effective.

You’ll appreciate these powerful benefits of IGF 1 LR3 just make sure you do not inject more than once per day.

It’s important to keep in mind the extremely long half-life of IGF 1 LR3 (20-30 hours) makes it unnecessary to supplement more than once in 24 hours.

Additionally, make sure to avoid using for longer than 30-60 days to avoid long-term effects that are irreversible (i.e. bubble gut).

Moreover, IGF 1 LR3 is really only effective if you are serious about gaining lean muscle and losing weight.

The hormone is incredibly powerful so it functions best when you pair it with an intense workout regime and nutrition plan.

In fact, most inject the substance shortly before a workout to maximize results.

Lastly, make sure you only shop for peptides from a reliable supplier.

We recommend Core Peptides for their affordable prices, quality, and selection.

Even better, the U.S.-based company has a strong reputation that dates back to 2013.

Where to Buy IGF 1 LR3?

IGF 1 LR3 is available from a variety of suppliers.

Nonetheless, we advise shopping with a trustworthy source like Core Peptides.

The company is an accredited quality assurance provider and offers dependable customer service.

Furthermore, the peptides the manufacturer produces are thoroughly tested using high-performance liquid chromatography-mass spectrometry (HPLC/MS).

IGF 1 LR3 from Core Peptides is available in lyophilized powder form shipped in 1mg vials.

Visit their official website here: www.CorePeptides.com

Conclusion: Stunning Muscle Growth

You’ll witness impressive muscle growth with IGF 1 LR3.

The long-form version of the Insulin-like Growth Factor (IGF) influences the production of Human Growth Hormone (HGH).

HGH is well regarded for its ability to promote new lean muscle and improved body mass.

Additionally, the peptide has the potential to assist in weight loss and other conditions (like diabetes).

There is little doubt that IGF 1 LR3 is effective at improving lean muscle and muscle mass.

Notwithstanding, make sure you exercise caution with use considering the potency.

IGF 1 LR3 is 3x more potent than its standard form so most keep cycles to under 30 days.

The powerful peptide functions best when you inject the substance shortly prior to a workout.

Those that supplement IGF 1 LR3 often experiment with a suitable dosage for their fitness goals.

If you are considering buying the peptide Core Peptides.

You can rely on their peptides for quality, consistency, and purity.


  1. Assefa B, Mahmoud AM, Pfeiffer AFH, Birkenfeld AL, Spranger J, Arafat AM. Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes. Oxid Med Cell Longev. 2017;2017:3035184. doi:10.1155/2017/3035184 (source)
  2. Philippou A, Barton ER. Optimizing IGF-I for skeletal muscle therapeutics. Growth Horm IGF Res. 2014;24(5):157-163. doi:10.1016/j.ghir.2014.06.003 (source)
  3. Bailes J, Soloviev M. Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports. Biomolecules. 2021;11(2):217. Published 2021 Feb 4. doi:10.3390/biom11020217 (source)
  4. Laron Z. Insulin-like growth factor 1 (IGF-1): a growth hormone. Mol Pathol. 2001;54(5):311-316. doi:10.1136/mp.54.5.311 (source)
  5. National Center for Corenology Information. PubChem Compound Summary for CID 126658, Human growth hormone (32-38). https://pubchem.ncbi.nlm.nih.gov/compound/Human-growth-hormone-_32-38. Accessed Aug. 8, 2022. (source)
  6. Serra C, Bhasin S, Tangherlini F, et al. The role of GH and IGF-I in mediating anabolic effects of testosterone on androgen-responsive muscle. Endocrinology. 2011;152(1):193-206. doi:10.1210/en.2010-0802 (source)
  7. Madathil SK, Saatman KE. IGF-1/IGF-R Signaling in Traumatic Brain Injury: Impact on Cell Survival, Neurogenesis, and Behavioral Outcome. In: Kobeissy FH, ed. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. (source)
  8. Tahimic CG, Wang Y, Bikle DD. Anabolic effects of IGF-1 signaling on the skeleton. Front Endocrinol (Lausanne). 2013;4:6. Published 2013 Feb 4. doi:10.3389/fendo.2013.00006 (source)
  9. National Research Council (US) Subcommittee on the Tenth Edition of the Recommended Dietary Allowances. Recommended Dietary Allowances: 10th Edition. Washington (DC): National Academies Press (US); 1989. 6, Protein and Amino Acids. (source)
  10. Tomas FM, Knowles SE, Owens PC, et al. Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats. Biochem J. 1992;282 ( Pt 1)(Pt 1):91-97. doi:10.1042/bj2820091 (source)
  11. von der Thüsen JH, Borensztajn KS, Moimas S, et al. IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype. Am J Pathol. 2011;178(2):924-934. doi:10.1016/j.ajpath.2010.10.007 (source)

See Also

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Rob V.
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IGF-1 LR-3

IGF-1 LR-3

4.8 out of 5 (27 Ratings)

IGF 1 LR3 is a potent peptide that is 3x more powerful than regular IGF. The substance generates HGH production for muscle growth
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